Next Article in Journal
Dietary Protein Consumption and the Risk of Type 2 Diabetes: ADose-Response Meta-Analysis of Prospective Studies
Next Article in Special Issue
Dietary Bean Consumption and Human Health
Previous Article in Journal
The Calorie and Nutrient Density of More- Versus Less-Processed Packaged Food and Beverage Products in the Canadian Food Supply
Previous Article in Special Issue
Improving the Health Benefits of Snap Bean: Genome-Wide Association Studies of Total Phenolic Content
Open AccessArticle

White Kidney Bean (Phaseolus Vulgaris L.) Consumption Reduces Fat Accumulation in a Polygenic Mouse Model of Obesity

1
Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
2
Proteomics and Metabolomics Facility, Colorado State University, Fort Collins, CO 80523, USA
3
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2780; https://doi.org/10.3390/nu11112780
Received: 24 October 2019 / Revised: 6 November 2019 / Accepted: 13 November 2019 / Published: 15 November 2019
(This article belongs to the Special Issue Dietary Bean Consumption and Human Health)
Clinical studies indicate that eating common bean, Phaseolus vulgaris L., plays a role in body weight regulation but mechanisms have yet to be elucidated. Here, we investigated the anti-obesogenic activity of white kidney bean in a mouse model of dietary-induced obesity. Bean consumption reduced the accumulation of adipose tissue in male and female C57BL6 mice. The anti-obesogenic effect of white kidney bean was not due to alterations in energy intake, energy excreted in the feces, or feed efficiency ratio. While bean consumption increased the mass of the intestine, no marked differences were consistently observed in crypt height, mucin content of goblet cells, proliferation index or zone of proliferation. However, significantly higher concentrations of total bacteria and of Akkermansia muciniphila were detected in cecal content of bean-fed mice, and the ratio of Firmicutes to Bacteroidetes was reduced. Bile acid content was higher in the ileum of bean-fed mice, but transcript levels of farnesoid X receptor were not significantly affected. Whether changes in bile-acid-mediated cell signaling play a role in bean-related differences in fat accumulation and/or overall metabolic health requires further investigation. View Full-Text
Keywords: Phaseolus vulgaris; white kidney bean; adiposity; obesity; gut health; Akkermansia muciniphila; Firmicutes to Bacteroidetes ratio; bile acids; farnesoid X receptor Phaseolus vulgaris; white kidney bean; adiposity; obesity; gut health; Akkermansia muciniphila; Firmicutes to Bacteroidetes ratio; bile acids; farnesoid X receptor
Show Figures

Figure 1

MDPI and ACS Style

Neil, E.S.; McGinley, J.N.; Fitzgerald, V.K.; Lauck, C.A.; Tabke, J.A.; Streeter-McDonald, M.R.; Yao, L.; Broeckling, C.D.; Weir, T.L.; Foster, M.T.; Thompson, H.J. White Kidney Bean (Phaseolus Vulgaris L.) Consumption Reduces Fat Accumulation in a Polygenic Mouse Model of Obesity. Nutrients 2019, 11, 2780.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop