White Kidney Bean (Phaseolus Vulgaris L.) Consumption Reduces Fat Accumulation in a Polygenic Mouse Model of Obesity

Neil, Elizabeth S.; McGinley, John N.; Fitzgerald, Vanessa K.; Lauck, Corey A.; Tabke, Jeremy A.; Streeter-McDonald, Madyson R.; Yao, Linxing; Broeckling, Corey D.; Weir, Tiffany L.; Foster, Michelle T.; Thompson, Henry J.

doi:10.3390/nu11112780

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White Kidney Bean (Phaseolus Vulgaris L.) Consumption Reduces Fat Accumulation in a Polygenic Mouse Model of Obesity

Elizabeth S. Neil

¹,

John N. McGinley

¹,

Vanessa K. Fitzgerald

¹,

Corey A. Lauck

¹,

Jeremy A. Tabke

¹,

Madyson R. Streeter-McDonald

¹,

²,

and

^1,*

Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA

Proteomics and Metabolomics Facility, Colorado State University, Fort Collins, CO 80523, USA

Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA

Author to whom correspondence should be addressed.

Nutrients 2019, 11(11), 2780; https://doi.org/10.3390/nu11112780

Received: 24 October 2019 / Revised: 6 November 2019 / Accepted: 13 November 2019 / Published: 15 November 2019

(This article belongs to the Special Issue Dietary Bean Consumption and Human Health)

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Abstract

Clinical studies indicate that eating common bean, Phaseolus vulgaris L., plays a role in body weight regulation but mechanisms have yet to be elucidated. Here, we investigated the anti-obesogenic activity of white kidney bean in a mouse model of dietary-induced obesity. Bean consumption reduced the accumulation of adipose tissue in male and female C57BL6 mice. The anti-obesogenic effect of white kidney bean was not due to alterations in energy intake, energy excreted in the feces, or feed efficiency ratio. While bean consumption increased the mass of the intestine, no marked differences were consistently observed in crypt height, mucin content of goblet cells, proliferation index or zone of proliferation. However, significantly higher concentrations of total bacteria and of Akkermansia muciniphila were detected in cecal content of bean-fed mice, and the ratio of Firmicutes to Bacteroidetes was reduced. Bile acid content was higher in the ileum of bean-fed mice, but transcript levels of farnesoid X receptor were not significantly affected. Whether changes in bile-acid-mediated cell signaling play a role in bean-related differences in fat accumulation and/or overall metabolic health requires further investigation. View Full-Text

Keywords: Phaseolus vulgaris; white kidney bean; adiposity; obesity; gut health; Akkermansia muciniphila; Firmicutes to Bacteroidetes ratio; bile acids; farnesoid X receptor

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MDPI and ACS Style

Neil, E.S.; McGinley, J.N.; Fitzgerald, V.K.; Lauck, C.A.; Tabke, J.A.; Streeter-McDonald, M.R.; Yao, L.; Broeckling, C.D.; Weir, T.L.; Foster, M.T.; Thompson, H.J. White Kidney Bean (Phaseolus Vulgaris L.) Consumption Reduces Fat Accumulation in a Polygenic Mouse Model of Obesity. Nutrients 2019, 11, 2780. https://doi.org/10.3390/nu11112780

AMA Style

Neil ES, McGinley JN, Fitzgerald VK, Lauck CA, Tabke JA, Streeter-McDonald MR, Yao L, Broeckling CD, Weir TL, Foster MT, Thompson HJ. White Kidney Bean (Phaseolus Vulgaris L.) Consumption Reduces Fat Accumulation in a Polygenic Mouse Model of Obesity. Nutrients. 2019; 11(11):2780. https://doi.org/10.3390/nu11112780

Chicago/Turabian Style

Neil, Elizabeth S., John N. McGinley, Vanessa K. Fitzgerald, Corey A. Lauck, Jeremy A. Tabke, Madyson R. Streeter-McDonald, Linxing Yao, Corey D. Broeckling, Tiffany L. Weir, Michelle T. Foster, and Henry J. Thompson. 2019. "White Kidney Bean (Phaseolus Vulgaris L.) Consumption Reduces Fat Accumulation in a Polygenic Mouse Model of Obesity" Nutrients 11, no. 11: 2780. https://doi.org/10.3390/nu11112780

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White Kidney Bean (Phaseolus Vulgaris L.) Consumption Reduces Fat Accumulation in a Polygenic Mouse Model of Obesity

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