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Article

β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Macrophages from Obese and Lean Mice: Effects of Exercise

1
Grupo de Investigación en Inmunofisiología, Departamento de Enfermería, Centro Universitario de Plasencia, Universidad de Extremadura, 10600 Plasencia, Spain
2
Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06071 Badajoz, Spain
3
Grupo de Investigación en Inmunofisiología, Departamento de Fisiología, Facultad de Ciencias, Universidad de Extremadura, 06071 Badajoz, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2019, 11(11), 2721; https://doi.org/10.3390/nu11112721
Received: 30 September 2019 / Revised: 31 October 2019 / Accepted: 7 November 2019 / Published: 9 November 2019
(This article belongs to the Special Issue Nutrition and Exercise Metabolism)
Macrophages are crucial in the inflammation associated with obesity. Exercise is the main non-pharmacological strategy against obesity, not only for improving metabolic impairment, but also because of its anti-inflammatory effects, particularly those mediated by β2 adrenergic receptors (β2-AR). Nevertheless, these anti-inflammatory effects could immunocompromise the innate response against pathogen challenge. Thus, the objective of this work was to evaluate the effect of obesity, and of exercise in this condition, on the β2 adrenergic regulation of the innate function of macrophages. High fat diet-induced obese C57BL/6J mice were used to evaluate the effects of acute and regular exercise on the phagocytic and microbicide capacities of peritoneal macrophages. Selective β2-AR agonist terbutaline (1 µM) decreased the phagocytic and microbicide activities of macrophages from control lean and obese sedentary animals. While acute exercise did not modify the inhibitory capacity of terbutaline, regular exercise abolished this inhibitory effect. These effects cannot be explained only by changes in the surface expression of β2-AR. In conclusion, (1) obesity does not alter the β2-AR-mediated decrease of the innate response of macrophages and (2) regular exercise can revert the inhibitory effect of terbutaline on the phagocytic activity of macrophages, although obesity seems to hinder this immunophysiological adaptation. View Full-Text
Keywords: β2 adrenoreceptors; macrophages; obesity; exercise; innate response; inflammation; phagocytosis; microbicide activity β2 adrenoreceptors; macrophages; obesity; exercise; innate response; inflammation; phagocytosis; microbicide activity
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MDPI and ACS Style

Martín-Cordero, L.; Gálvez, I.; Hinchado, M.D.; Ortega, E. β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Macrophages from Obese and Lean Mice: Effects of Exercise. Nutrients 2019, 11, 2721. https://doi.org/10.3390/nu11112721

AMA Style

Martín-Cordero L, Gálvez I, Hinchado MD, Ortega E. β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Macrophages from Obese and Lean Mice: Effects of Exercise. Nutrients. 2019; 11(11):2721. https://doi.org/10.3390/nu11112721

Chicago/Turabian Style

Martín-Cordero, Leticia, Isabel Gálvez, María Dolores Hinchado, and Eduardo Ortega. 2019. "β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Macrophages from Obese and Lean Mice: Effects of Exercise" Nutrients 11, no. 11: 2721. https://doi.org/10.3390/nu11112721

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