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Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus

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University of Sorocaba, Sorocaba-SP 18023-000, Brazil
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Department of Veterinary Clinical Sciences, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo 18610-307, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2720; https://doi.org/10.3390/nu11112720
Received: 11 October 2019 / Revised: 4 November 2019 / Accepted: 7 November 2019 / Published: 9 November 2019
(This article belongs to the Special Issue The Application of Mushrooms or Mushroom Extracts to Enhance Health)
Background: The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. Methods: On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. Results: The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. Conclusions: Lentinus edodes mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus. View Full-Text
Keywords: Lentinus edodes; mushroom nutraceuticals; gestational diabetes mellitus; anti-diabetic activity; pre-clinical study Lentinus edodes; mushroom nutraceuticals; gestational diabetes mellitus; anti-diabetic activity; pre-clinical study
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Laurino, L.F.; Viroel, F.J.M.; Caetano, E.; Spim, S.; Pickler, T.B.; Rosa-Castro, R.M.; Vasconcelos, E.A.; Jozala, A.F.; Hataka, A.; Grotto, D.; Gerenutti, M. Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus. Nutrients 2019, 11, 2720.

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