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Review

Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus

1
Department of Pharmacology, School of Pharmacy, Universidad de Granada, 18071 Granada, Spain
2
Gene Regulation in Cardiovascular Remodeling and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain
3
Ciber Enfermedades Cardiovasculares (CiberCV), 28029 Madrid, Spain
4
Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), 18012 Granada, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Nutrients 2019, 11(11), 2676; https://doi.org/10.3390/nu11112676
Received: 14 October 2019 / Revised: 25 October 2019 / Accepted: 28 October 2019 / Published: 5 November 2019
(This article belongs to the Special Issue Dietary Polyphenols and Cardiometabolic Diseases)
The prevalence of renal and cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is higher than in general populations. Recently, a causal role of gut microbiota on the development of immune responses in SLE has been described. Probiotic consumption changes the composition of gut microbiota, preventing SLE progression. The aim of this review is to explore the role of the gut microbiota in the development of renal and cardiovascular disease in SLE and how probiotics could be a therapeutic option. Despite strong evidence on the beneficial effects of probiotics in the development of autoimmunity and nephritis in SLE, only a few studies described the protective effects of Lactobacillus in important risk factors for CVD, such as endothelial dysfunction and hypertension in mice. The preventive effects of probiotics in renal and CVD in humans have not been established yet. View Full-Text
Keywords: immune response; gut microbiota; hypertension; endothelial dysfunction; nephritis immune response; gut microbiota; hypertension; endothelial dysfunction; nephritis
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MDPI and ACS Style

de la Visitación, N.; Robles-Vera, I.; Toral, M.; Duarte, J. Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus. Nutrients 2019, 11, 2676. https://doi.org/10.3390/nu11112676

AMA Style

de la Visitación N, Robles-Vera I, Toral M, Duarte J. Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus. Nutrients. 2019; 11(11):2676. https://doi.org/10.3390/nu11112676

Chicago/Turabian Style

de la Visitación, Néstor, Iñaki Robles-Vera, Marta Toral, and Juan Duarte. 2019. "Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus" Nutrients 11, no. 11: 2676. https://doi.org/10.3390/nu11112676

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