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Article

Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells

1
Neonatal Research Group, Health Research Institute La Fe, 46026 Valencia, Spain
2
Division of Neonatology, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain
3
Department of Biotechnology, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), 46980 Valencia, Spain
4
Department of Physiology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2677; https://doi.org/10.3390/nu11112677
Received: 8 October 2019 / Revised: 28 October 2019 / Accepted: 30 October 2019 / Published: 5 November 2019
(This article belongs to the Special Issue Fortification of Human Milk in the Neonatal Intensive Care Unit)
Background: Own mother’s milk (OMM) is the optimal nutrition for preterm infants. However, pasteurized donor human milk (DHM) is a valid alternative. We explored the differences of the transcriptome in exfoliated epithelial intestinal cells (EEIC) of preterm infants receiving full feed with OMM or DHM. Methods: The prospective observational study included preterm infants ≤ 32 weeks’ gestation and/or ≤1500 g birthweight. Total RNA from EEIC were processed for genome-wide expression analysis. Results: Principal component analysis and unsupervised hierarchical clustering analysis revealed two clustered groups corresponding to the OMM and DHM groups that showed differences in the gene expression profile in 1629 transcripts. The OMM group overexpressed lactalbumin alpha gene (LALBA), Cytochrome C oxidase subunit I gene (COX1) and caseins kappa gene (CSN3), beta gene (CSN2) and alpha gene (CSN1S1) and underexpressed Neutrophil Cytosolic Factor 1 gene (NCF1) compared to the DHM group. Conclusions: The transcriptomic analysis of EEIC showed that OMM induced a differential expression of specific genes that may contribute to a more efficient response to a pro-oxidant challenge early in the postnatal period when preterm infants are at a higher risk of oxidative stress. The use of OMM should be strongly promoted in preterm infants. View Full-Text
Keywords: prematurity; mother’s milk; donor milk; genetics; intestinal cells; inflammation; oxidative stress prematurity; mother’s milk; donor milk; genetics; intestinal cells; inflammation; oxidative stress
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MDPI and ACS Style

Parra-Llorca, A.; Gormaz, M.; Lorente-Pozo, S.; Cernada, M.; García-Robles, A.; Torres-Cuevas, I.; Kuligowski, J.; Collado, M.C.; Serna, E.; Vento, M. Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells. Nutrients 2019, 11, 2677. https://doi.org/10.3390/nu11112677

AMA Style

Parra-Llorca A, Gormaz M, Lorente-Pozo S, Cernada M, García-Robles A, Torres-Cuevas I, Kuligowski J, Collado MC, Serna E, Vento M. Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells. Nutrients. 2019; 11(11):2677. https://doi.org/10.3390/nu11112677

Chicago/Turabian Style

Parra-Llorca, Anna, María Gormaz, Sheila Lorente-Pozo, Maria Cernada, Ana García-Robles, Isabel Torres-Cuevas, Julia Kuligowski, Maria C. Collado, Eva Serna, and Máximo Vento. 2019. "Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells" Nutrients 11, no. 11: 2677. https://doi.org/10.3390/nu11112677

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