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Curcumin, Hormesis and the Nervous System

Curcumin, Gut Microbiota, and Neuroprotection

Institute of Biosciences and BioResources-UOS Naples CNR, Via P. Castellino, 80100 Naples, Italy
Department of Biology, University of Naples Federico II, Complesso Universitario Monte Sant’Angelo via Cinthia, 80100 Naples, Italy
Institute of Research on Terrestrial Ecosystems, 05010 Porano TR, Italy
Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via Santa Maria di Costantinopoli, 80100 Naples, Italy
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2426;
Received: 31 August 2019 / Revised: 29 September 2019 / Accepted: 4 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Dietary Curcumin and Human Health)
Curcumin, a nontoxic, naturally occurring polyphenol, has been recently proposed for the management of neurodegenerative and neurological diseases. However, a discrepancy exists between the well-documented pharmacological activities that curcumin seems to possess in vivo and its poor aqueous solubility, bioavailability, and pharmacokinetic profiles that should limit any therapeutic effect. Thus, it is possible that curcumin could exert direct regulative effects primarily in the gastrointestinal tract, where high concentrations of curcumin are present after oral administration. Indeed, a new working hypothesis that could explain the neuroprotective role of curcumin despite its limited availability is that curcumin acts indirectly on the central nervous system by influencing the “microbiota–gut–brain axis”, a complex bidirectional system in which the microbiome and its composition represent a factor which preserves and determines brain “health”. Interestingly, curcumin and its metabolites might provide benefit by restoring dysbiosis of gut microbiome. Conversely, curcumin is subject to bacterial enzymatic modifications, forming pharmacologically more active metabolites than curcumin. These mutual interactions allow to keep proper individual physiologic functions and play a key role in neuroprotection. View Full-Text
Keywords: curcumin; gut microbioma; polyphenols; bioactivity; metabolism; neuroprotection curcumin; gut microbioma; polyphenols; bioactivity; metabolism; neuroprotection
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MDPI and ACS Style

Di Meo, F.; Margarucci, S.; Galderisi, U.; Crispi, S.; Peluso, G. Curcumin, Gut Microbiota, and Neuroprotection. Nutrients 2019, 11, 2426.

AMA Style

Di Meo F, Margarucci S, Galderisi U, Crispi S, Peluso G. Curcumin, Gut Microbiota, and Neuroprotection. Nutrients. 2019; 11(10):2426.

Chicago/Turabian Style

Di Meo, Francesco, Sabrina Margarucci, Umberto Galderisi, Stefania Crispi, and Gianfranco Peluso. 2019. "Curcumin, Gut Microbiota, and Neuroprotection" Nutrients 11, no. 10: 2426.

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