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Curcumin, Hormesis and the Nervous System

Department of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia, 97–95125 Catania, Italy
Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
Institute of Pharmacology, Catholic University of Sacred Heart, 00168 Roma, Italy
Department of Clinical and experimental Medicine, Division of Endocrinology, University of Catania, 95125 Catania, Italy
Department of Medical and Surgery Sciences, University of Catania, 95125 Catania, Italy
Department of Environmental Health Sciences, School of Public Health and Health Science, University of Massachusetts, Amherst, MA 01003, USA
Author to whom correspondence should be addressed.
The authors contributed equally to this article.
Nutrients 2019, 11(10), 2417;
Received: 28 August 2019 / Revised: 1 October 2019 / Accepted: 1 October 2019 / Published: 10 October 2019
(This article belongs to the Special Issue Dietary Curcumin and Human Health)
Curcumin is a polyphenol compound extracted from the rhizome of Curcuma longa Linn (family Zingiberaceae) commonly used as a spice to color and flavor food. Several preclinical studies have suggested beneficial roles for curcumin as an adjuvant therapy in free radical-based diseases, mainly neurodegenerative disorders. Indeed, curcumin belongs to the family of hormetins and the enhancement of the cell stress response, mainly the heme oxygenase-1 system, is actually considered the common denominator for this dual response. However, evidence-based medicine has clearly demonstrated the lack of any therapeutic effect of curcumin to contrast the onset or progression of neurodegeneration and related diseases. Finally, the curcumin safety profile imposes a careful analysis of the risk/benefit balance prior to proposing chronic supplementation with curcumin. View Full-Text
Keywords: hormesis; vitagenes; antioxidants; heme oxygenase hormesis; vitagenes; antioxidants; heme oxygenase
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Concetta Scuto, M.; Mancuso, C.; Tomasello, B.; Laura Ontario, M.; Cavallaro, A.; Frasca, F.; Maiolino, L.; Trovato Salinaro, A.; Calabrese, E.J.; Calabrese, V. Curcumin, Hormesis and the Nervous System. Nutrients 2019, 11, 2417.

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