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Curcumin, Hormesis and the Nervous System

1
Department of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia, 97–95125 Catania, Italy
2
Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
3
Institute of Pharmacology, Catholic University of Sacred Heart, 00168 Roma, Italy
4
Department of Clinical and experimental Medicine, Division of Endocrinology, University of Catania, 95125 Catania, Italy
5
Department of Medical and Surgery Sciences, University of Catania, 95125 Catania, Italy
6
Department of Environmental Health Sciences, School of Public Health and Health Science, University of Massachusetts, Amherst, MA 01003, USA
*
Author to whom correspondence should be addressed.
The authors contributed equally to this article.
Nutrients 2019, 11(10), 2417; https://doi.org/10.3390/nu11102417
Received: 28 August 2019 / Revised: 1 October 2019 / Accepted: 1 October 2019 / Published: 10 October 2019
(This article belongs to the Special Issue Dietary Curcumin and Human Health)
Curcumin is a polyphenol compound extracted from the rhizome of Curcuma longa Linn (family Zingiberaceae) commonly used as a spice to color and flavor food. Several preclinical studies have suggested beneficial roles for curcumin as an adjuvant therapy in free radical-based diseases, mainly neurodegenerative disorders. Indeed, curcumin belongs to the family of hormetins and the enhancement of the cell stress response, mainly the heme oxygenase-1 system, is actually considered the common denominator for this dual response. However, evidence-based medicine has clearly demonstrated the lack of any therapeutic effect of curcumin to contrast the onset or progression of neurodegeneration and related diseases. Finally, the curcumin safety profile imposes a careful analysis of the risk/benefit balance prior to proposing chronic supplementation with curcumin. View Full-Text
Keywords: hormesis; vitagenes; antioxidants; heme oxygenase hormesis; vitagenes; antioxidants; heme oxygenase
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Concetta Scuto, M.; Mancuso, C.; Tomasello, B.; Laura Ontario, M.; Cavallaro, A.; Frasca, F.; Maiolino, L.; Trovato Salinaro, A.; Calabrese, E.J.; Calabrese, V. Curcumin, Hormesis and the Nervous System. Nutrients 2019, 11, 2417.

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