Next Article in Journal
Role of Milk-Derived Opioid Peptides and Proline Dipeptidyl Peptidase-4 in Autism Spectrum Disorders
Next Article in Special Issue
Bamboo Stems (Phyllostachys nigra variety henosis) Containing Polyphenol Mixtures Activate Nrf2 and Attenuate Phenylhydrazine-Induced Oxidative Stress and Liver Injury
Previous Article in Journal
The Role of Nutrients in Reducing the Risk for Noncommunicable Diseases during Aging
Previous Article in Special Issue
Pistachio Consumption Prevents and Improves Lipid Dysmetabolism by Reducing the Lipid Metabolizing Gene Expression in Diet-Induced Obese Mice
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 11
Issue 1
10.3390/nu11010086
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Effect of Wakame and Carob Pod Snacks on Non-Alcoholic Fatty Liver Disease

by
Daniel Rico
1,
Ana Belén Martin-Diana
1,
Arrate Lasa
2,3,*,
Leixuri Aguirre
2,3,
Iñaki Milton-Laskibar
2,3,
Daniel Antonio De Luis
4 and
Jonatan Miranda
2,3
1
Department of Research and Technology, Agrarian Technological Institute of Castilla and Leon (ITACyL), Government of Castilla and Leon, Ctra. de Burgos Km. 119, 47071 Valladolid, Spain
2
Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy, University of Basque Country (UPV/EHU) and Lucio Lascaray Research Center, 01006 Vitoria, Spain
3
CIBEROBN Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), 01006 Vitoria-Gasteiz, Spain
4
Endocrinology and Nutrition Department, Hospital Clínico Universitario de Valladolid-IEN, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(1), 86; https://doi.org/10.3390/nu11010086
Submission received: 23 November 2018 / Revised: 16 December 2018 / Accepted: 28 December 2018 / Published: 4 January 2019
(This article belongs to the Special Issue Liver, Oxidative Stress and Metabolic Syndromes)
Browse Figures
Review Reports Versions Notes

Abstract

Snacks combining different functional ingredients could represent a useful therapeutic strategy against NAFLD. The present study aimed to analyze the effect of two snack formulations based on carob and wakame flour in the treatment for NAFLD in rats. For this purpose, metabolic syndrome was induced in 50 adult rats by a high-fat high-fructose diet over eight weeks. After this period, rats were fed either normal calorie diets supplemented or not with snack A (1/50 wakame/carob pod) and snack B (1/5 wakame/carob pod) for four additional weeks. After sacrifice, liver composition and serum parameters were analyzed. Different pathways of triacylglycerol metabolism in liver were studied including fatty acid oxidation, fatty acid synthesis, triglyceride assembly and release, fatty acid uptake and glucose uptake. Oxidative stress was also measured. Snack treatment, and mainly B snack, reduced liver triacylglycerol levels by increasing fat oxidation. Moreover, this snack reduced oxidative stress. Therefore, this snack formulation could represent an interesting tool useful for fatty liver treatment.
Keywords: wakame; carob; snack; steatohepatitis; NAFLD wakame; carob; snack; steatohepatitis; NAFLD
Graphical Abstract

Share and Cite

MDPI and ACS Style

Rico, D.; Martin-Diana, A.B.; Lasa, A.; Aguirre, L.; Milton-Laskibar, I.; De Luis, D.A.; Miranda, J. Effect of Wakame and Carob Pod Snacks on Non-Alcoholic Fatty Liver Disease. Nutrients 2019, 11, 86. https://doi.org/10.3390/nu11010086

AMA Style

Rico D, Martin-Diana AB, Lasa A, Aguirre L, Milton-Laskibar I, De Luis DA, Miranda J. Effect of Wakame and Carob Pod Snacks on Non-Alcoholic Fatty Liver Disease. Nutrients. 2019; 11(1):86. https://doi.org/10.3390/nu11010086

Chicago/Turabian Style

Rico, Daniel, Ana Belén Martin-Diana, Arrate Lasa, Leixuri Aguirre, Iñaki Milton-Laskibar, Daniel Antonio De Luis, and Jonatan Miranda. 2019. "Effect of Wakame and Carob Pod Snacks on Non-Alcoholic Fatty Liver Disease" Nutrients 11, no. 1: 86. https://doi.org/10.3390/nu11010086

APA Style

Rico, D., Martin-Diana, A. B., Lasa, A., Aguirre, L., Milton-Laskibar, I., De Luis, D. A., & Miranda, J. (2019). Effect of Wakame and Carob Pod Snacks on Non-Alcoholic Fatty Liver Disease. Nutrients, 11(1), 86. https://doi.org/10.3390/nu11010086

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop