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Open AccessArticle

Prevention of Rotavirus Diarrhea in Suckling Rats by a Specific Fermented Milk Concentrate with Prebiotic Mixture

1
Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l’Alimentació, University of Barcelona (UB), Av. Joan XXIII 27-31, 08028 Barcelona, Spain
2
Institut de Recerca en Nutrició i Seguretat Alimentària (INSA), C/ Prat de la Riba 171, Santa Coloma de Gramanet, 08921 Barcelona, Spain
3
Danone Nutricia Research, 3584 Utrecht, The Netherlands
4
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3512 Utrecht, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(1), 189; https://doi.org/10.3390/nu11010189
Received: 12 December 2018 / Revised: 14 January 2019 / Accepted: 14 January 2019 / Published: 18 January 2019
(This article belongs to the Special Issue Health Benefits of Fermentation)
Several microbial modulatory concepts, such as certain probiotics and prebiotics, confer protection against gastrointestinal infections, among which is acute diarrhea caused by the rotavirus (RV). Other microbiota modulators, such as postbiotics, produced during fermentation, might also have the potential to counteract RV infection. In light of this, a fermented milk, made by using Bifidobacterium breve C50 (BbC50) and Streptococcus thermophilus 065 (St065) with a prebiotic mixture—short chain galactooligosaccharides/long chain fructooligosaccharides (scGOS/lcFOS 9:1)—with potential to impact the intestinal microbiota composition was tested. An RV infected rat model was used to evaluate the amelioration of the infectious process and the improvement of the immune response induced by the fermented milk with prebiotic mixture. The dietary intervention caused a reduction in the clinical symptoms of diarrhea, such as severity and incidence. Furthermore, a modulation of the immune response was observed, which might enhance the reduction of the associated diarrhea. In addition, the fermented milk with prebiotic mixture was able to bind the virus and reduce its clearance. In conclusion, the postbiotic components in the fermented milk in combination with the prebiotics used here showed protective properties against RV infection. View Full-Text
Keywords: fermented formula; probiotic; prebiotic; postbiotic; rotavirus fermented formula; probiotic; prebiotic; postbiotic; rotavirus
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MDPI and ACS Style

Rigo-Adrover, M.d.M.; Knipping, K.; Garssen, J.; van Limpt, K.; Knol, J.; Franch, À.; Castell, M.; Rodríguez-lagunas, M.J.; Pérez-Cano, F.J. Prevention of Rotavirus Diarrhea in Suckling Rats by a Specific Fermented Milk Concentrate with Prebiotic Mixture. Nutrients 2019, 11, 189. https://doi.org/10.3390/nu11010189

AMA Style

Rigo-Adrover MdM, Knipping K, Garssen J, van Limpt K, Knol J, Franch À, Castell M, Rodríguez-lagunas MJ, Pérez-Cano FJ. Prevention of Rotavirus Diarrhea in Suckling Rats by a Specific Fermented Milk Concentrate with Prebiotic Mixture. Nutrients. 2019; 11(1):189. https://doi.org/10.3390/nu11010189

Chicago/Turabian Style

Rigo-Adrover, Maria d.M.; Knipping, Karen; Garssen, Johan; van Limpt, Kees; Knol, Jan; Franch, Àngels; Castell, Margarida; Rodríguez-lagunas, Maria J.; Pérez-Cano, Francisco J. 2019. "Prevention of Rotavirus Diarrhea in Suckling Rats by a Specific Fermented Milk Concentrate with Prebiotic Mixture" Nutrients 11, no. 1: 189. https://doi.org/10.3390/nu11010189

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