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Resveratrol and Its Human Metabolites—Effects on Metabolic Health and Obesity

1
Nestle Institute of Health Sciences, Nestle Research, EPFL Innovation Park, Building H, 1015 Lausanne, Switzerland
2
TUM Graduate School, Technical University of Munich, 85748 Munich, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(1), 143; https://doi.org/10.3390/nu11010143
Received: 22 November 2018 / Revised: 6 January 2019 / Accepted: 8 January 2019 / Published: 11 January 2019
(This article belongs to the Special Issue Benefits of Resveratrol Supplementation)
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Abstract

Resveratrol is one of the most widely studied polyphenols and it has been assigned a plethora of metabolic effects with potential health benefits. Given its low bioavailability and extensive metabolism, clinical studies using resveratrol have not always replicated in vitro observations. In this review, we discuss human metabolism and biotransformation of resveratrol, and reported molecular mechanisms of action, within the context of metabolic health and obesity. Resveratrol has been described as mimicking caloric restriction, leading to improved exercise performance and insulin sensitivity (increasing energy expenditure), as well as having a body fat-lowering effect by inhibiting adipogenesis, and increasing lipid mobilization in adipose tissue. These multi-organ effects place resveratrol as an anti-obesity bioactive of potential therapeutic use. View Full-Text
Keywords: resveratrol; polyphenols; metabolism; obesity; diabetes; metabolic pathways resveratrol; polyphenols; metabolism; obesity; diabetes; metabolic pathways
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Springer, M.; Moco, S. Resveratrol and Its Human Metabolites—Effects on Metabolic Health and Obesity. Nutrients 2019, 11, 143.

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