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Nutrients 2018, 10(8), 956; https://doi.org/10.3390/nu10080956

A Synergistic Formulation of Plant Extracts Decreases Postprandial Glucose and Insulin Peaks: Results from Two Randomized, Controlled, Cross-Over Studies Using Real-World Meals

1
Clinical Research Centre, Medical University of Bialystok, M.C. Sklodowskiej 24A, 15-276 Bialystok, Poland
2
Marmar Investments Sp. z o.o., Slominskiego 15, lok 509, 00-195 Warsaw, Poland
3
Department of Endocrinology, Diabetology, and Internal Medicine, Medical University of Bialystok, M.C. Sklodowskiej 24A, 15-276 Bialystok, Poland
4
Department of Neurological Rehabilitation, Gothenburg University Hospital, SE-405 30 Gothenburg, Sweden
Marcin Krotkiewski sadly passed away before the manuscript was submitted.
*
Author to whom correspondence should be addressed.
Received: 13 June 2018 / Revised: 19 July 2018 / Accepted: 23 July 2018 / Published: 25 July 2018
(This article belongs to the Special Issue Appetite, Metabolism and Obesity)
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Abstract

This study investigated the efficacy of a plant-derived dietary supplement with respect to decreasing postprandial glucose and insulin peaks after the intake of real-world meals. Two randomized, double-blind, placebo-controlled, cross-over experiments were conducted on healthy subjects who received a supplement containing extracts of white mulberry, white bean, and green coffee or one containing the three extracts with added fibre before consuming high-GI/GL (glycaemic index/glycaemic load) meals. In study one, 32 subjects received an investigational product/placebo before a standardized meal at two visits. In study two, 150 subjects received an investigational product/placebo before five different standardized meals. Postprandial glucose and insulin concentrations were lower 20–35 min after meal intake among subjects taking the investigational product, and fewer episodes of postprandial reactive hypoglycaemia were noted. For example, after consuming breakfast cereal with milk, lower glucose peaks were observed for the investigational product (vs. placebo) after 20 min (100.2 ± 1.97 vs. 112.5 ± 3.12 mg/dL, respectively; p < 0.01); lower insulin peaks were noted at the same time point (45.9 ± 4.02 IU/mL vs. 68.2 ± 5.53 IU/mL, respectively, p < 0.01). The combined formulation decreases the adverse consequences of high-GI/GL meal consumption. It can be an effective dietary supplement for the management of metabolic syndrome and type 2 diabetes mellitus. View Full-Text
Keywords: plant extracts; natural product; postprandial glucose peaks; postprandial insulin peaks; pre-diabetes; metabolic syndrome; type 2 diabetes; overweight; obesity plant extracts; natural product; postprandial glucose peaks; postprandial insulin peaks; pre-diabetes; metabolic syndrome; type 2 diabetes; overweight; obesity
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Adamska-Patruno, E.; Billing-Marczak, K.; Orlowski, M.; Gorska, M.; Krotkiewski, M.; Kretowski, A. A Synergistic Formulation of Plant Extracts Decreases Postprandial Glucose and Insulin Peaks: Results from Two Randomized, Controlled, Cross-Over Studies Using Real-World Meals. Nutrients 2018, 10, 956.

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