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Open AccessArticle

Orosensory Detection of Dietary Fatty Acids Is Altered in CB1R−/− Mice

1
Physiology of Nutrition and Toxicology (NUTox), INSERM UMR U1231, Université de Bourgogne Franche-Comté/Agro-Sup, 21000 Dijon, France
2
Pathophysiology of Dyslipidemia (PADYS), INSERM UMR U1231, Université de Bourgogne Franche-Comté/AgroSup, 21000 Dijon, France
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1347; https://doi.org/10.3390/nu10101347
Received: 12 August 2018 / Revised: 14 September 2018 / Accepted: 18 September 2018 / Published: 21 September 2018
(This article belongs to the Special Issue Appetite, Metabolism and Obesity)
Obesity is one of the major public health issues, and its prevalence is steadily increasing all the world over. The endocannabinoid system (ECS) has been shown to be involved in the intake of palatable food via activation of cannabinoid 1 receptor (CB1R). However, the involvement of lingual CB1R in the orosensory perception of dietary fatty acids has never been investigated. In the present study, behavioral tests on CB1R−/− and wild type (WT) mice showed that the invalidation of Cb1r gene was associated with low preference for solutions containing rapeseed oil or a long-chain fatty acid (LCFA), such as linoleic acid (LA). Administration of rimonabant, a CB1R inverse agonist, in mice also brought about a low preference for dietary fat. No difference in CD36 and GPR120 protein expressions were observed in taste bud cells (TBC) from WT and CB1R−/− mice. However, LCFA induced a higher increase in [Ca2+]i in TBC from WT mice than that in TBC from CB1R−/− mice. TBC from CB1R−/− mice also exhibited decreased Proglucagon and Glp-1r mRNA and a low GLP-1 basal level. We report that CB1R is involved in fat taste perception via calcium signaling and GLP-1 secretion. View Full-Text
Keywords: nutrition; lipids; fat taste; CD36; feeding behavior; cannabinoids; CB1R; GLP-1 nutrition; lipids; fat taste; CD36; feeding behavior; cannabinoids; CB1R; GLP-1
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Brissard, L.; Leemput, J.; Hichami, A.; Passilly-Degrace, P.; Maquart, G.; Demizieux, L.; Degrace, P.; Khan, N.A. Orosensory Detection of Dietary Fatty Acids Is Altered in CB1R−/− Mice. Nutrients 2018, 10, 1347.

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