Next Article in Journal
Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium
Next Article in Special Issue
A Low FODMAP Gluten-Free Diet Improves Functional Gastrointestinal Disorders and Overall Mental Health of Celiac Disease Patients: A Randomized Controlled Trial
Previous Article in Journal
Effectiveness of a Locally Produced, Fish-Based Food Product on Weight Gain among Cambodian Children in the Treatment of Acute Malnutrition: A Randomized Controlled Trial
Previous Article in Special Issue
The Effect of Depressive Symptoms on the Association between Gluten-Free Diet Adherence and Symptoms in Celiac Disease: Analysis of a Patient Powered Research Network
Open AccessArticle

Effects of a Gluten-Containing Meal on Gastric Emptying and Gallbladder Contraction

1
Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
2
Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy
3
Alphasearch, 20100 Milan, Italy
4
Center for the Prevention and Diagnosis of Celiac Disease, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(7), 910; https://doi.org/10.3390/nu10070910
Received: 28 May 2018 / Revised: 25 June 2018 / Accepted: 12 July 2018 / Published: 16 July 2018
(This article belongs to the Special Issue Gluten-Free Diet)
The ingestion of gluten has been associated with gastrointestinal symptoms even in the absence of detectable immune responses. Little is known about the pathophysiological effects of gluten on the upper gastrointestinal tract. We aimed to assess whether the ingestion of gluten leads to an impairment of the physiological mechanisms of gastric emptying, gallbladder contraction and relaxation. A total of 17 healthy subjects underwent ultrasound evaluation of gastric emptying dynamics and gallbladder contractions at baseline and every 30 min after a standard gluten-containing and gluten-free meal (250 kcal, 70% carbohydrates). The pattern of gastric emptying was similar after a standard meal with or without gluten, but differed in terms of the peak of the antral filling curve, which was wider (mean area 5.69, median 4.70, range 3.71‒9.27 cm2 vs. mean 4.89, median 4.57, 2.27‒10.22 cm2, p = 0.023) after the gluten-containing meal. The pattern of gallbladder contractions was different after the gluten-free meal (p < 0.05), with higher gallbladder volumes in the late refilling phases. The results of this study show that gluten ingestion exerts objective effects on gastric and gallbladder motility. Although the underlying pathophysiological mechanism remains unknown, these results could account for some of the gluten-related symptoms reported by patients with celiac disease and non-celiac gluten sensitivity. View Full-Text
Keywords: gluten; gastric emptying; cholecyst; celiac disease; non celiac gluten sensitivity gluten; gastric emptying; cholecyst; celiac disease; non celiac gluten sensitivity
Show Figures

Figure 1

MDPI and ACS Style

Massironi, S.; Branchi, F.; Fraquelli, M.; Baccarin, A.; Somalvico, F.; Ferretti, F.; Conte, D.; Elli, L. Effects of a Gluten-Containing Meal on Gastric Emptying and Gallbladder Contraction. Nutrients 2018, 10, 910.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop