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Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium

Department of Pharmacology and Therapeutics and Department of Physiology, University College Cork, T12 K8AF Cork, Ireland
School of Food and Nutritional Sciences, University College Cork, T12 K8AF Cork, Ireland
APC Microbiome Ireland, University College Cork, T12 K8AF Cork, Ireland
Marigot Ltd., P43 NN62 Cork, Ireland
Author to whom correspondence should be addressed.
Nutrients 2018, 10(7), 912;
Received: 31 May 2018 / Revised: 4 July 2018 / Accepted: 11 July 2018 / Published: 17 July 2018
(This article belongs to the Special Issue Magnesium Intake and Human Health)
Introduction: Magnesium is an essential mineral involved in a range of key biochemical pathways. Several magnesium supplements are present on the market and their degree of bioavailability differs depending on the form of magnesium salt used. Aquamin-Mg is a natural source of magnesium, containing 72 additional trace minerals derived from the clean waters off the Irish coast. However, the in vitro bioaccessibility and bioavailability of Aquamin-Mg in comparison with other supplement sources of magnesium has yet to be tested. Method: Aquamin-Mg, magnesium chloride (MgCl2) and magnesium oxide (MgO) were subjected to gastrointestinal digestion according to the harmonized INFOGEST in vitro digestion method and in vitro bioavailability tested using the Caco-2 cell model. Magnesium concentration was measured by atomic absorption spectrophotometry (AAS). Results: Magnesium recovery from both Aquamin-Mg and MgCl2 was greater than for MgO. Magnesium from all three sources was transported across the epithelial monolayer with Aquamin-Mg displaying a comparable profile to the more bioavailable MgCl2. Conclusions: Our data support that magnesium derived from a marine-derived multimineral product is bioavailable to a significantly greater degree than MgO and displays a similar profile to the more bioavailable MgCl2 and may offer additional health benefits given its multimineral profile. View Full-Text
Keywords: Aquamin; multimineral supplement; magnesium bioavailability Aquamin; multimineral supplement; magnesium bioavailability
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Felice, V.D.; O’Gorman, D.M.; O’Brien, N.M.; Hyland, N.P. Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium. Nutrients 2018, 10, 912.

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