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Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium

1
Department of Pharmacology and Therapeutics and Department of Physiology, University College Cork, T12 K8AF Cork, Ireland
2
School of Food and Nutritional Sciences, University College Cork, T12 K8AF Cork, Ireland
3
APC Microbiome Ireland, University College Cork, T12 K8AF Cork, Ireland
4
Marigot Ltd., P43 NN62 Cork, Ireland
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(7), 912; https://doi.org/10.3390/nu10070912
Received: 31 May 2018 / Revised: 4 July 2018 / Accepted: 11 July 2018 / Published: 17 July 2018
(This article belongs to the Special Issue Magnesium Intake and Human Health)
Introduction: Magnesium is an essential mineral involved in a range of key biochemical pathways. Several magnesium supplements are present on the market and their degree of bioavailability differs depending on the form of magnesium salt used. Aquamin-Mg is a natural source of magnesium, containing 72 additional trace minerals derived from the clean waters off the Irish coast. However, the in vitro bioaccessibility and bioavailability of Aquamin-Mg in comparison with other supplement sources of magnesium has yet to be tested. Method: Aquamin-Mg, magnesium chloride (MgCl2) and magnesium oxide (MgO) were subjected to gastrointestinal digestion according to the harmonized INFOGEST in vitro digestion method and in vitro bioavailability tested using the Caco-2 cell model. Magnesium concentration was measured by atomic absorption spectrophotometry (AAS). Results: Magnesium recovery from both Aquamin-Mg and MgCl2 was greater than for MgO. Magnesium from all three sources was transported across the epithelial monolayer with Aquamin-Mg displaying a comparable profile to the more bioavailable MgCl2. Conclusions: Our data support that magnesium derived from a marine-derived multimineral product is bioavailable to a significantly greater degree than MgO and displays a similar profile to the more bioavailable MgCl2 and may offer additional health benefits given its multimineral profile. View Full-Text
Keywords: Aquamin; multimineral supplement; magnesium bioavailability Aquamin; multimineral supplement; magnesium bioavailability
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Felice, V.D.; O’Gorman, D.M.; O’Brien, N.M.; Hyland, N.P. Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium. Nutrients 2018, 10, 912.

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