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Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial

Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Department of Preventive Medicine and Public Health, University of Navarra-IdiSNA, 31008 Pamplona, Spain
Department of Biochemistry and Biotechnology, Human Nutrition Unit, Universitat Rovira i Virgili, 43204 Reus, Spain
Institut d’Investigació Sanitària Pere Virgili (IISPV), 43204 Reus, Spain
Department of Internal Medicine. University Hospital of Sant Joan de Reus, 43204 Reus, Spain
Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain
Cardiovascular Risk and Nutrition, IMIM-Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain
Blanquerna School of Life Sciences, Universitat Ramon Llull, 08025 Barcelona, Spain
Consorcio CIBER, M.P. Epidemiología y Salud Pública (CIBEREsp), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Nutritional Epidemiology Unit, Miguel Hernández University, ISABIAL-FISABIO, 46020 Alicante, Spain
Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
IMDEA Food, CEI UAM + CSIC, 28049 Madrid, Spain
Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases, 07120 Palma de Mallorca, Spain
School of Health Sciences. University of Málaga-IBIMA, 29010 Malaga, Spain
Department of Internal Medicine, Reina Sofia University Hospital, University of Córdoba-IMIBIC, 14004 Córdoba, Spain
Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
Department of Preventive Medicine, University of Granada, 18016 Granada, Spain
Department of Cardiology OSI ARABA, University Hospital Araba, 01009 Vitoria, Spain
Department of Medicine, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain
Research Group on Community Nutrition and Oxidative Stress, Universitat de les Illes Balears, 07122 Palma de Mallorca, Spain
Department of Endocrinology, University Hospital, University of Málaga, 29010 Málaga, Spain
Atención Primaria, Osasunbidea-Servicio Navarro de Salud, 31002 Pamplona, Spain
Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain
Department of Family Medicine, Distrito Sanitario Atencion Primaria, Centro de Salud Las Palmeritas, 41005 Sevilla, Spain
Department of Endocrinology, Fundación Jiménez-Díaz, 28040 Madrid, Spain
Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, 08907 Barcelona, Spain
Consorcio CIBER, M.P. Diabetes y enfermedades metabólicas (CIBERDem), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Department of Endocrinology, IDIBAPS, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
Division of Preventive Medicine, University of Jaén, 23071 Jaén, Spain
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040 Madrid, Spain
Lipids and Cardiovascular Epidemiology Research Unit, Institut Municipal d’Investigació Mèdica (IMIM), 08003 Barcelona, Spain
Primary Health Care Division. Institut Català de la Salut and IDIAPJgol, 08007 Barcelona, Spain
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA
Ecoaqua Institute, University of Las Palmas de Gran Canaria, 35214 Telde, Spain
Author to whom correspondence should be addressed.
Nutrients 2018, 10(12), 2000;
Received: 29 September 2018 / Revised: 14 November 2018 / Accepted: 20 November 2018 / Published: 18 December 2018
(This article belongs to the Special Issue Fish and Meat Consumption: Risks and Benefits)
Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. Results: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63–0.94), 0.71 (0.58–0.87), and 0.78 (0.64–0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5–1 g/day) was significantly associated with a lower prevalence of depression. Conclusion: In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship. View Full-Text
Keywords: fish; omega-3; eicosapentaenoic acid; docosahexaenoic acid; depression fish; omega-3; eicosapentaenoic acid; docosahexaenoic acid; depression
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MDPI and ACS Style

Sánchez-Villegas, A.; Álvarez-Pérez, J.; Toledo, E.; Salas-Salvadó, J.; Ortega-Azorín, C.; Zomeño, M.D.; Vioque, J.; Martínez, J.A.; Romaguera, D.; Pérez-López, J.; López-Miranda, J.; Estruch, R.; Bueno-Cavanillas, A.; Arós, F.; Tur, J.A.; Tinahones, F.J.; Lecea, O.; Martín, V.; Ortega-Calvo, M.; Vázquez, C.; Pintó, X.; Vidal, J.; Daimiel, L.; Delgado-Rodríguez, M.; Matía, P.; Corella, D.; Díaz-López, A.; Babio, N.; Muñoz, M.Á.; Fitó, M.; García de la Hera, M.; Abete, I.; García-Rios, A.; Ros, E.; Ruíz-Canela, M.; Martínez-González, M.Á.; Izquierdo, M.; Serra-Majem, L. Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial. Nutrients 2018, 10, 2000.

AMA Style

Sánchez-Villegas A, Álvarez-Pérez J, Toledo E, Salas-Salvadó J, Ortega-Azorín C, Zomeño MD, Vioque J, Martínez JA, Romaguera D, Pérez-López J, López-Miranda J, Estruch R, Bueno-Cavanillas A, Arós F, Tur JA, Tinahones FJ, Lecea O, Martín V, Ortega-Calvo M, Vázquez C, Pintó X, Vidal J, Daimiel L, Delgado-Rodríguez M, Matía P, Corella D, Díaz-López A, Babio N, Muñoz MÁ, Fitó M, García de la Hera M, Abete I, García-Rios A, Ros E, Ruíz-Canela M, Martínez-González MÁ, Izquierdo M, Serra-Majem L. Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial. Nutrients. 2018; 10(12):2000.

Chicago/Turabian Style

Sánchez-Villegas, Almudena, Jacqueline Álvarez-Pérez, Estefanía Toledo, Jordi Salas-Salvadó, Carolina Ortega-Azorín, Maria D. Zomeño, Jesús Vioque, Jose A. Martínez, Dora Romaguera, Jessica Pérez-López, José López-Miranda, Ramón Estruch, Aurora Bueno-Cavanillas, Fernando Arós, Josep A. Tur, Francisco J. Tinahones, Oscar Lecea, Vicente Martín, M. Ortega-Calvo, Clotilde Vázquez, Xavier Pintó, Josep Vidal, Lidia Daimiel, Miguel Delgado-Rodríguez, Pilar Matía, Dolores Corella, Andrés Díaz-López, Nancy Babio, Miguel Á. Muñoz, Montserrat Fitó, Manoli García de la Hera, Itziar Abete, Antonio García-Rios, Emilio Ros, Miguel Ruíz-Canela, Miguel Á. Martínez-González, Marisol Izquierdo, and Lluis Serra-Majem. 2018. "Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial" Nutrients 10, no. 12: 2000.

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