Next Article in Journal
Sugar-Sweetened Beverage Intake among Chilean Preschoolers and Adolescents in 2016: A Cross-Sectional Analysis
Next Article in Special Issue
Improved Preventive Effects of Combined Bioactive Compounds Present in Different Blueberry Varieties as Compared to Single Phytochemicals
Previous Article in Journal
Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer’s Disease
Previous Article in Special Issue
Redox Homeostasis and Natural Dietary Compounds: Focusing on Antioxidants of Rice (Oryza sativa L.)
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Nutrients 2018, 10(11), 1766; https://doi.org/10.3390/nu10111766

Changing to a Low-Polyphenol Diet Alters Vascular Biomarkers in Healthy Men after Only Two Weeks

1
Department of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
2
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain
3
INSA-UB, Nutrition and Food Safety Research Institute, University of Barcelona, 08028 Barcelona, Spain
4
Department of Endocrinology & Nutrition, CIBER of Diabetes and Associated Metabolic Diseases, Biomedical Reseacrh Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain
5
Cardiovascular Epidemiology and Genetics Group, REGICOR, IMIM (Instituto Hospital del Mar de Investigaciones Médicas), 08003 Barcelona, Spain
6
Center for the Biomedical Research Network in Cardiovascular Diseases (CIBERCV), Institute of Health Carlos III, 28029 Madrid, Spain
7
Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Center, University Rovira i Virgili, 43201 Reus, Spain
*
Author to whom correspondence should be addressed.
Received: 26 October 2018 / Revised: 10 November 2018 / Accepted: 12 November 2018 / Published: 14 November 2018
(This article belongs to the Special Issue Phytochemicals in Health and Disease)
  |  
PDF [2297 KB, uploaded 19 November 2018]
  |     |  

Abstract

Bioactive dietary compounds play a critical role in health maintenance. The relation between bioactive compound intake and cardiovascular health-related biomarkers has been demonstrated in several studies, although mainly with participants who have altered biochemical parameters (high blood pressure, high cholesterol, metabolic syndrome, etc.). The aim of this study was to evaluate if adopting a diet low in polyphenol-rich food for two weeks would affect vascular biomarkers in healthy men. In a crossover study, 22 healthy men were randomly assigned to their usual diet (UD), consuming healthy food rich in polyphenols, or to a low antioxidant diet (LAD), with less than two servings of fruit and vegetables per day and avoiding the intake of cocoa products, coffee and tea. As a marker of compliance, total polyphenols in urine were significantly lower after the LAD than after the UD (79 ± 43 vs. 123 ± 58 mg GAE/g creatinine). Nitric oxide levels were also reduced (52 ± 28 in LAD vs. 80 ± 34 µM in UD), although no significant changes in cellular adhesion molecules and eicosanoids were observed; however, an increasing ratio between thromboxane A2 (TXA2) and prostaglandin I2 (PGI2) was reached (p = 0.048). Thus, a slight dietary modification, reducing the consumption of polyphenol-rich food, may affect vascular biomarkers even in healthy individuals. View Full-Text
Keywords: bioactive compounds; nitric oxide; vascular biomarkers; low antioxidant diet; Mediterranean diet; eicosanoids; adhesion molecules bioactive compounds; nitric oxide; vascular biomarkers; low antioxidant diet; Mediterranean diet; eicosanoids; adhesion molecules
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Hurtado-Barroso, S.; Quifer-Rada, P.; Rinaldi de Alvarenga, J.F.; Pérez-Fernández, S.; Tresserra-Rimbau, A.; Lamuela-Raventos, R.M. Changing to a Low-Polyphenol Diet Alters Vascular Biomarkers in Healthy Men after Only Two Weeks. Nutrients 2018, 10, 1766.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top