Next Article in Journal
Multidomain Lifestyle Intervention Strategies for the Delay of Cognitive Impairment in Healthy Aging
Next Article in Special Issue
Possible Role of CYP450 Generated Omega-3/Omega-6 PUFA Metabolites in the Modulation of Blood Pressure and Vascular Function in Obese Children
Previous Article in Journal
Sex-Dimorphic Association of Plasma Fatty Acids with Cardiovascular Fitness in Young and Middle-Aged General Adults: Subsamples from NHANES 2003–2004
Previous Article in Special Issue
Erucic Acid (22:1n-9) in Fish Feed, Farmed, and Wild Fish and Seafood Products
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Nutrients 2018, 10(10), 1559; https://doi.org/10.3390/nu10101559

Uncommon Fatty Acids and Cardiometabolic Health

1
Institute of Nutrition and Health, Qingdao University, Qingdao 266021, China
2
Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC 3220, Australia
3
Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, VIC 3168, Australia
*
Author to whom correspondence should be addressed.
Received: 7 September 2018 / Revised: 15 October 2018 / Accepted: 18 October 2018 / Published: 20 October 2018
(This article belongs to the Special Issue Fatty Acids and Cardiometabolic Health)
Full-Text   |   PDF [846 KB, uploaded 23 October 2018]   |  

Abstract

Cardiovascular disease (CVD) is a major cause of mortality. The effects of several unsaturated fatty acids on cardiometabolic health, such as eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA), α linolenic acid (ALA), linoleic acid (LA), and oleic acid (OA) have received much attention in past years. In addition, results from recent studies revealed that several other uncommon fatty acids (fatty acids present at a low content or else not contained in usual foods), such as furan fatty acids, n-3 docosapentaenoic acid (DPA), and conjugated fatty acids, also have favorable effects on cardiometabolic health. In the present report, we searched the literature in PubMed, Embase, and the Cochrane Library to review the research progress on anti-CVD effect of these uncommon fatty acids. DPA has a favorable effect on cardiometabolic health in a different way to other long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs), such as EPA and DHA. Furan fatty acids and conjugated linolenic acid (CLNA) may be potential bioactive fatty acids beneficial for cardiometabolic health, but evidence from intervention studies in humans is still limited, and well-designed clinical trials are required. The favorable effects of conjugated linoleic acid (CLA) on cardiometabolic health observed in animal or in vitro cannot be replicated in humans. However, most intervention studies in humans concerning CLA have only evaluated its effect on cardiometabolic risk factors but not its direct effect on risk of CVD, and randomized controlled trials (RCTs) will be required to clarify this point. However, several difficulties and limitations exist for conducting RCTs to evaluate the effect of these fatty acids on cardiometabolic health, especially the high costs for purifying the fatty acids from natural sources. This review provides a basis for better nutritional prevention and therapy of CVD. View Full-Text
Keywords: furan fatty acids; docosapentaenoic acid; conjugated fatty acids; cardiovascular disease; metabolic disease; blood lipids; inflammation; antioxidant furan fatty acids; docosapentaenoic acid; conjugated fatty acids; cardiovascular disease; metabolic disease; blood lipids; inflammation; antioxidant
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Li, K.; Sinclair, A.J.; Zhao, F.; Li, D. Uncommon Fatty Acids and Cardiometabolic Health. Nutrients 2018, 10, 1559.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top