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Nutrients 2018, 10(10), 1485;

Effects of Glycine on Collagen, PDGF, and EGF Expression in Model of Oral Mucositis

Department of Pediatrics, Federal University of São Paulo, São Paulo 04023-062, Brazil
Former Head Division of Dentistry, Pediatric Oncology Institute, São Paulo 04023-062, Brazil
Department of Pathology, Federal University of São Paulo, São Paulo 04023-062, Brazil
Department of Pediatrics, IOP/GRAACC Medical School of Federal University of São Paulo, São Paulo 04023-062, Brazil
Author to whom correspondence should be addressed.
Received: 10 July 2018 / Revised: 3 September 2018 / Accepted: 5 September 2018 / Published: 12 October 2018
(This article belongs to the Special Issue Advances in Dietary Supplements)
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Oral mucositis is frequently a toxic effect of chemotherapeutic and/or radiotherapeutic treatment, resulting from complex multifaceted biological events involving DNA damage. The clinical manifestations have a negative impact on the life quality of cancer patients. Preventive measures and curative treatment of mucositis are still not well established. The glycine has anti-inflammatory, immunomodulatory, and cytoprotective actions, being a potential therapeutic in mucositis. The objective was to evaluate the effects of glycine on the expression of collagen and growth factors, platelet and epidermal in a hamster model oral mucositis. The mucositis was induced by the protocol of Sonis. There were 40 hamsters used, divided into two groups: Group I-control; Group II-supplemented with 5% intraperitoneal glycine, 2.0 mg/g diluted in hepes. Histopathological sections were used to perform the immune-histochemical method, the evaluation of collagen expression, and the growth factors: Epidermal growth factor (EGF) and platelet (PDGF). It was observed that the group supplemented with glycine experienced higher amounts of collagen expression and predominance type of collagen I. The glycine group presented lower immunoexpression of the growth factors, EGF and PDGF. The group supplemented with glycine showed a marked healing process of the oral mucosite, demonstrated by the predominance of collagen type I and reduction of growth factors, EGF and PDGF. View Full-Text
Keywords: oral mucositis; glycine; intercellular signaling peptides; proteins oral mucositis; glycine; intercellular signaling peptides; proteins

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Sá, O.M.S.; Lopes, N.N.F.; Alves, M.T.S.; Caran, E.M.M. Effects of Glycine on Collagen, PDGF, and EGF Expression in Model of Oral Mucositis. Nutrients 2018, 10, 1485.

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