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Thalassemia Reports
Volume 13
Issue 2
10.3390/thalassrep13020015
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Review

The Benign Clone Causing Aplastic Anaemia

by
Shaun R. McCann
1,* and
Andrea Piccin
2,3,4
1
Department of Haematology, Trinity College, 2 Dublin, Ireland
2
Northern Ireland Blood Transfusion Service (NIBTS), Belfast BT9 7TS, UK
3
Department of Internal Medicine V, Medical University of Innsbruck, 6020 Innsbruck, Austria
4
Department of Industrial Engineering, University of Trento, 38122 Trento, Italy
*
Author to whom correspondence should be addressed.
Thalass. Rep. 2023, 13(2), 157-164; https://doi.org/10.3390/thalassrep13020015
Submission received: 29 November 2022 / Revised: 8 June 2023 / Accepted: 8 June 2023 / Published: 12 June 2023
(This article belongs to the Special Issue Thalassemia Syndromes as a Benign Cancer of Hematopoietic Stem Cells)
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Abstract

Severe Aplastic Anaemia (SAA) is a rare benign disease but carries a high-mortality rate unless treated in a specialised centre. Overwhelming laboratory and clinical evidence points to an autoimmune pathogenesis; although, the aetiology remains obscure in the majority of cases. The differential diagnosis in older patients is problematical and a diagnosis of hypoplastic myelodysplasia remains difficult. This review points out the difficulty in diagnosis without a specific test. Future research needs to define a specific diagnostic test and refine therapeutic interventions.
Keywords: aplastic anaemia; clonality; SAA; HSCT aplastic anaemia; clonality; SAA; HSCT

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MDPI and ACS Style

McCann, S.R.; Piccin, A. The Benign Clone Causing Aplastic Anaemia. Thalass. Rep. 2023, 13, 157-164. https://doi.org/10.3390/thalassrep13020015

AMA Style

McCann SR, Piccin A. The Benign Clone Causing Aplastic Anaemia. Thalassemia Reports. 2023; 13(2):157-164. https://doi.org/10.3390/thalassrep13020015

Chicago/Turabian Style

McCann, Shaun R., and Andrea Piccin. 2023. "The Benign Clone Causing Aplastic Anaemia" Thalassemia Reports 13, no. 2: 157-164. https://doi.org/10.3390/thalassrep13020015

APA Style

McCann, S. R., & Piccin, A. (2023). The Benign Clone Causing Aplastic Anaemia. Thalassemia Reports, 13(2), 157-164. https://doi.org/10.3390/thalassrep13020015

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