Cationic Nanoparticle-Based Cancer Vaccines
Abstract
:1. Introduction
2. Cationic Nanoparticles in Cancer Vaccine Design
2.1. Cationic Nanoparticles Improve Vaccine Efficacy
2.2. Types of Cationic Nanoparticles in Cancer Vaccines
2.3. Types of Antigenic Molecules in Cationic Nanoparticulate Cancer Vaccine Formulations
2.4. Antigen Classes in Cancer Vaccines
2.4.1. Tumor-Associated Antigens
2.4.2. Viral Oncoproteins
2.4.3. Neoantigens
3. Biodistribution of Cationic Nanoparticulate Vaccines
4. Cationic Nanoparticles: Molecular Mechanism of Action
4.1. Immunostimulatory Effects of Cationic Lipids and Polymers in Nanoparticles
4.2. Enhanced Cross-Presentation by Cationic Lipids and Polymers in Cationic Nanoparticles
5. Conclusions and Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Study Type | Antigen Source | Particle Type | Cationic Component | Type of Antigen | Molecular Adjuvant | Administration Route | Reference |
---|---|---|---|---|---|---|---|
Murine | |||||||
Preclinical | Ovalbumin | Liposomes | DOTAP | Peptide | Poly [I:C] | i.d. | [67] |
Preclinical | TC-1 & Melanoma (B16-F10) | Liposomes | DOTAP | Peptide | Poly [I:C] | i.d. | [29,68] |
Preclinical | TC-1 & Melanoma (B16-OVA) | Liposomes | DDA | Protein Peptide | Poly [I:C] | i.p. | [69,70] |
Preclinical | TC-1 | Liposomes | DOTAP | Peptide Lipopeptide | n.a. | s.c. | [71,72,73,74,75] |
Preclinical | Melanoma (B16-F10) | Liposomes | DOTAP | Peptide | n.a. | s.c. | [76] |
Preclinical | Hepatoma (Hepa 1–6) | Liposomes | DOTAP | Tumor lysate | Poly [I:C] | i.p. | [77] |
Preclinical | Glioma (GL261) | Liposomes | TMAG | Tumor extract | n.a. | i.p. | [78] |
Preclinical | Melanoma (B16-BL6) | Liposomes | DOTMA | Plasmid DNA | Mannose | i.p. | [79] |
Preclinical | Colon carcinoma (CT-26) | Liposomes & w/o/w emulsion | DC-Chol | Peptide | Pam2Cys | p.o. | [80] |
Preclinical | Melanoma (B16-F10 & BPD6) | LCP nanoparticles | DOTAP | Peptide mRNA | Mannose CpG | s.c. | [81,82,83] |
Preclinical | Breast cancer | LCP nanoparticles | DOTAP | mRNA | Mannose | s.c. | [84] |
Preclinical | Colon carcinoma (CT-26) | LCP nanoparticles | DOTAP | mRNA | Mannose CpG cGAMP | s.c. | [85] |
Preclinical | Thymic lymphoma (E.G7-OVA) | Lipid-polymer nanoparticles | DOTAP | Protein | Mannose Imiquimod MPLA | s.c. | [86] |
Preclinical | Thymic Lymphoma (E.G7-OVA) | Lipid-polymer Nanoparticles | Non disclosed lipid | mRNA | n.a. | i.v. | [87] |
Preclinical | Ovalbumin | Polymer-based | Methacrylated dextran | Peptide | Poly [I:C] | i.d. | [30] |
Preclinical | TC-1, Melanoma, Colon carcinoma (B16-OVA & CT-26) | Lipoplexes | DOTMA | mRNA | n.a. | i.v. | [9,14] |
Preclinical | Colon carcinoma (MC-38 & CT-26) | Lipoplexes | DOTMA | Peptide | CpG | i.v. & s.c. | [35] |
Preclinical | Colon carcinoma (MC-38), Melanoma (B16-F10 & B16.OVA), TC-1 | Self-assembling nanoparticles | Amino acid sequence | Peptide | Imidazoquinoline- based TLR 7/8a | i.v. & s.c. | [33,34] |
Human | |||||||
Phase I | Melanoma | Lipoplexes | DOTMA | mRNA | n.a. | i.v. | [9] |
Phase I | Prostate cancer | Liposomes | DDA | Peptide | Poly [I:C] | i.p. & i.m. | [88] |
Phase I/IIa | Melanoma, NSCLC, Bladder cancer | Liposomes | DDA | Peptide | Poly [I:C] | i.p.& i.m. | [89] |
Route of Administration | Biodistribution Profiles | Ref |
---|---|---|
Intradermal (i.d.) | - Depot formation at the SOI - Prolonged Ag presentation at the SOI - Prolonged Ag presentation in draining lymph nodes | [29,62,67,68] |
Subcutaneous (s.c.) | - Depot formation at the SOI - Prolonged Ag presentation at the SOI - Prolonged Ag presentation in draining lymph nodes | [62,71,73,75,94,95,96,107,120] |
Intramuscular (i.m.) | - Depot formation at the SOI - Prolonged Ag presentation at the SOI | [95,96,107,121,122,123] |
Intraperitoneal (i.p.) | - Rapid drainage to multiple lymphoid organs - Limited/no depot formation | [26,62,69,89,124] |
Intravenously (i.v.) | - Systemic Ag exposure - Uptake by splenic DCs - Uptake by APCs in lungs | [9,10,33,34,62,125,126] |
Intranodal (i.n.) | - High vaccine concentration in lymph nodes - Complex injection (ultra-sound or tracer guided) | [119,127,128,129] |
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Heuts, J.; Jiskoot, W.; Ossendorp, F.; van der Maaden, K. Cationic Nanoparticle-Based Cancer Vaccines. Pharmaceutics 2021, 13, 596. https://doi.org/10.3390/pharmaceutics13050596
Heuts J, Jiskoot W, Ossendorp F, van der Maaden K. Cationic Nanoparticle-Based Cancer Vaccines. Pharmaceutics. 2021; 13(5):596. https://doi.org/10.3390/pharmaceutics13050596
Chicago/Turabian StyleHeuts, Jeroen, Wim Jiskoot, Ferry Ossendorp, and Koen van der Maaden. 2021. "Cationic Nanoparticle-Based Cancer Vaccines" Pharmaceutics 13, no. 5: 596. https://doi.org/10.3390/pharmaceutics13050596
APA StyleHeuts, J., Jiskoot, W., Ossendorp, F., & van der Maaden, K. (2021). Cationic Nanoparticle-Based Cancer Vaccines. Pharmaceutics, 13(5), 596. https://doi.org/10.3390/pharmaceutics13050596