Next Article in Journal
Perspective on Global Measles Epidemiology and Control and the Role of Novel Vaccination Strategies
Next Article in Special Issue
Envelope Protein Mutations L107F and E138K Are Important for Neurovirulence Attenuation for Japanese Encephalitis Virus SA14-14-2 Strain
Previous Article in Journal
The Astrovirus Capsid: A Review
Previous Article in Special Issue
Mx Is Not Responsible for the Antiviral Activity of Interferon-α against Japanese Encephalitis Virus
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview

The IMPORTance of the Nucleus during Flavivirus Replication

Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia
Department of Physiology, Anatomy & Microbiology, La Trobe University, Melbourne 3086, Australia
Author to whom correspondence should be addressed.
Academic Editor: Michael Holbrook
Viruses 2017, 9(1), 14;
Received: 16 December 2016 / Revised: 10 January 2017 / Accepted: 12 January 2017 / Published: 19 January 2017
(This article belongs to the Special Issue Advances in Flavivirus Research)
PDF [791 KB, uploaded 19 January 2017]


Flaviviruses are a large group of arboviruses of significant medical concern worldwide. With outbreaks a common occurrence, the need for efficient viral control is required more than ever. It is well understood that flaviviruses modulate the composition and structure of membranes in the cytoplasm that are crucial for efficient replication and evading immune detection. As the flavivirus genome consists of positive sense RNA, replication can occur wholly within the cytoplasm. What is becoming more evident is that some viral proteins also have the ability to translocate to the nucleus, with potential roles in replication and immune system perturbation. In this review, we discuss the current understanding of flavivirus nuclear localisation, and the function it has during flavivirus infection. We also describe—while closely related—the functional differences between similar viral proteins in their nuclear translocation. View Full-Text
Keywords: flavivirus; nucleus; transport; karyopherins; nuclear pore complex; nuclear localisation sequence flavivirus; nucleus; transport; karyopherins; nuclear pore complex; nuclear localisation sequence

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Lopez-Denman, A.J.; Mackenzie, J.M. The IMPORTance of the Nucleus during Flavivirus Replication. Viruses 2017, 9, 14.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top