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Ubiquitin in Influenza Virus Entry and Innate Immunity

by Alina Rudnicka 1 and Yohei Yamauchi 1,2,3,*
1
Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich CH-8057, Switzerland
2
School of Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK
3
Structural Biology Research Center, Department of Biological Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Eric Freed and Thomas Klimkait
Viruses 2016, 8(10), 293; https://doi.org/10.3390/v8100293
Received: 14 September 2016 / Revised: 14 October 2016 / Accepted: 14 October 2016 / Published: 24 October 2016
(This article belongs to the Special Issue Viruses 2016 - At the Forefront of Virus-Host Interactions)
Viruses are obligatory cellular parasites. Their mission is to enter a host cell, to transfer the viral genome, and to replicate progeny whilst diverting cellular immunity. The role of ubiquitin is to regulate fundamental cellular processes such as endocytosis, protein degradation, and immune signaling. Many viruses including influenza A virus (IAV) usurp ubiquitination and ubiquitin-like modifications to establish infection. In this focused review, we discuss how ubiquitin and unanchored ubiquitin regulate IAV host cell entry, and how histone deacetylase 6 (HDAC6), a cytoplasmic deacetylase with ubiquitin-binding activity, mediates IAV capsid uncoating. We also discuss the roles of ubiquitin in innate immunity and its implications in the IAV life cycle. View Full-Text
Keywords: ubiquitin; unanchored ubiquitin; HDAC6; aggresome processing; influenza virus; virus entry; virus uncoating; innate immunity; virus–host interactions ubiquitin; unanchored ubiquitin; HDAC6; aggresome processing; influenza virus; virus entry; virus uncoating; innate immunity; virus–host interactions
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Rudnicka, A.; Yamauchi, Y. Ubiquitin in Influenza Virus Entry and Innate Immunity. Viruses 2016, 8, 293.

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