Viruses 2016, 8(10), 269; https://doi.org/10.3390/v8100269
Multi-Omics Studies towards Novel Modulators of Influenza A Virus–Host Interaction
Sandra Söderholm 1,2, Yu Fu 3, Lana Gaelings 3, Sergey Belanov 3
, Laxman Yetukuri 3, Mikhail Berlinkov 4, Anton V. Cheltsov 5, Simon Anders 3, Tero Aittokallio 3,6, Tuula A. Nyman 7, Sampsa Matikainen 2,8 and Denis E. Kainov 3,*
, Laxman Yetukuri 3, Mikhail Berlinkov 4, Anton V. Cheltsov 5, Simon Anders 3, Tero Aittokallio 3,6, Tuula A. Nyman 7, Sampsa Matikainen 2,8 and Denis E. Kainov 3,*
1
Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland
2
Finnish Institute of Occupational Health, Helsinki 00250, Finland
3
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00014, Finland
4
Institute of Mathematics and Computer Science, Ural Federal University, Yekaterinburg 620083, Russia
5
Q-Mol L.L.C. in Silico Pharmaceuticals, San Diego, CA 92037, USA
6
Department of Mathematics and Statistics, University of Turku, Turku 20014, Finland
7
Institute of Clinical Medicine, Oslo 0450, Norway
8
Department of Rheumatology, Helsinki University Hospital, University of Helsinki, Helsinki 00015, Finland
*
Author to whom correspondence should be addressed.
Academic Editors: Eric O. Freed and Thomas Klimkait
Received: 28 July 2016 / Revised: 13 September 2016 / Accepted: 22 September 2016 / Published: 29 September 2016
(This article belongs to the Special Issue Viruses 2016 - At the Forefront of Virus-Host Interactions)
Abstract
Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV–host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 199 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the 665 remains unknown. Studying anti-influenza efficacy and immuno/neuro-modulating properties of these compounds and their combinations as well as potential viral and host resistance to them may lead to the discovery of novel modulators of IAV–host interactions, which might be more effective than the currently available anti-influenza therapeutics. View Full-TextKeywords:
influenza virus; antiviral agent; proteomics; phosphoproteomics; metabolomics; transcriptomics; genomics; virtual ligand screening
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MDPI and ACS Style
Söderholm, S.; Fu, Y.; Gaelings, L.; Belanov, S.; Yetukuri, L.; Berlinkov, M.; Cheltsov, A.V.; Anders, S.; Aittokallio, T.; Nyman, T.A.; Matikainen, S.; Kainov, D.E. Multi-Omics Studies towards Novel Modulators of Influenza A Virus–Host Interaction. Viruses 2016, 8, 269.
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