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Viruses 2015, 7(10), 5489-5507;

The Role of Cytokines and Chemokines in Filovirus Infection

United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Frederick, MD 21702, USA
Author to whom correspondence should be addressed.
Academic Editor: Jens H. Kuhn
Received: 1 September 2015 / Revised: 9 October 2015 / Accepted: 14 October 2015 / Published: 23 October 2015
(This article belongs to the Collection Advances in Ebolavirus, Marburgvirus, and Cuevavirus Research)
PDF [3974 KB, uploaded 23 October 2015]


Ebola- and marburgviruses are highly pathogenic filoviruses and causative agents of viral hemorrhagic fever. Filovirus disease is characterized by a dysregulated immune response, severe organ damage, and coagulation abnormalities. This includes modulation of cytokines, signaling mediators that regulate various components of the immune system as well as other biological processes. Here we examine the role of cytokines in filovirus infection, with an emphasis on understanding how these molecules affect development of the antiviral immune response and influence pathology. These proteins may present targets for immune modulation by therapeutic agents and vaccines in an effort to boost the natural immune response to infection and/or reduce immunopathology. View Full-Text
Keywords: Filovirus; Ebola; Marburg; cytokine; chemokine; immunopathology Filovirus; Ebola; Marburg; cytokine; chemokine; immunopathology

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Bixler, S.L.; Goff , A.J. The Role of Cytokines and Chemokines in Filovirus Infection. Viruses 2015, 7, 5489-5507.

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