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Viruses 2018, 10(9), 473;

Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview

Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
Author to whom correspondence should be addressed.
Received: 10 August 2018 / Revised: 1 September 2018 / Accepted: 2 September 2018 / Published: 3 September 2018
(This article belongs to the Special Issue Recent Advances of Natural Products in HSV Research)
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The herpes simplex virus (HSV) is a common human virus affecting many people worldwide. HSV infections manifest with lesions that occur in different parts of the body, including oral, ocular, nasal, and genital skin and mucosa. In rare cases, HSV infections can be serious and lethal. Several anti-HSV drugs have been developed, but the existence of mutant viruses resistant to these drugs led to the individuation of novel antiviral agents. Plant-derived bioactive compounds, and more specifically polyphenols, have been demonstrated to exert marked anti-HSV activity and, among these, resveratrol (RSV) would be considered a good candidate. The purpose of this manuscript is to review the available literature elucidating the efficacy of RSV against HSV and the main demonstrated mechanisms of action. View Full-Text
Keywords: herpes simplex virus; HSV-1; HSV-2; resveratrol; polyphenols; nutraceutical herpes simplex virus; HSV-1; HSV-2; resveratrol; polyphenols; nutraceutical

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Annunziata, G.; Maisto, M.; Schisano, C.; Ciampaglia, R.; Narciso, V.; Tenore, G.C.; Novellino, E. Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview. Viruses 2018, 10, 473.

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