Next Article in Journal
A Human DPP4-Knockin Mouse’s Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV
Next Article in Special Issue
The Interplay between Human Cytomegalovirus and Pathogen Recognition Receptor Signaling
Previous Article in Journal
The Morphology and Assembly of Respiratory Syncytial Virus Revealed by Cryo-Electron Tomography
Previous Article in Special Issue
US28: HCMV’s Swiss Army Knife
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Viruses 2018, 10(9), 447; https://doi.org/10.3390/v10090447

Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling

Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
*
Author to whom correspondence should be addressed.
Received: 3 August 2018 / Revised: 17 August 2018 / Accepted: 18 August 2018 / Published: 21 August 2018
(This article belongs to the Special Issue Recent Advances in Cytomegalovirus Research)
Full-Text   |   PDF [1116 KB, uploaded 21 August 2018]   |  

Abstract

As essential components of the host’s innate immune response, NFκB and interferon signaling are critical determinants of the outcome of infection. Over the past 25 years, numerous Human Cytomegalovirus (HCMV) genes have been identified that antagonize or modulate the signaling of these pathways. Here we review the biology of the HCMV factors that alter NFκB and interferon signaling, including what is currently known about how these viral genes contribute to infection and persistence, as well as the major outstanding questions that remain. View Full-Text
Keywords: human cytomegalovirus; HCMV; NFκB; interferon; IκB kinase (IKK); ISG human cytomegalovirus; HCMV; NFκB; interferon; IκB kinase (IKK); ISG
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Goodwin, C.M.; Ciesla, J.H.; Munger, J. Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling. Viruses 2018, 10, 447.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top