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Viruses 2018, 10(9), 447;

Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling

Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
Author to whom correspondence should be addressed.
Received: 3 August 2018 / Revised: 17 August 2018 / Accepted: 18 August 2018 / Published: 21 August 2018
(This article belongs to the Special Issue Recent Advances in Cytomegalovirus Research)
Full-Text   |   PDF [1116 KB, uploaded 21 August 2018]   |  


As essential components of the host’s innate immune response, NFκB and interferon signaling are critical determinants of the outcome of infection. Over the past 25 years, numerous Human Cytomegalovirus (HCMV) genes have been identified that antagonize or modulate the signaling of these pathways. Here we review the biology of the HCMV factors that alter NFκB and interferon signaling, including what is currently known about how these viral genes contribute to infection and persistence, as well as the major outstanding questions that remain. View Full-Text
Keywords: human cytomegalovirus; HCMV; NFκB; interferon; IκB kinase (IKK); ISG human cytomegalovirus; HCMV; NFκB; interferon; IκB kinase (IKK); ISG

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Goodwin, C.M.; Ciesla, J.H.; Munger, J. Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling. Viruses 2018, 10, 447.

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