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Volume 13
Issue 7
10.3390/ma13071748
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Review

Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review

by
Barbara Kołodziejska
,
Agnieszka Kaflak
and
Joanna Kolmas
*
Chair of Analytical Chemistry and Biomaterials, Department of Analytical Chemistry, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Materials 2020, 13(7), 1748; https://doi.org/10.3390/ma13071748
Submission received: 7 March 2020 / Revised: 30 March 2020 / Accepted: 7 April 2020 / Published: 9 April 2020
(This article belongs to the Special Issue Bio-Inspired Materials for Biomedical Applications)
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Abstract

Type I collagen and nanocrystalline-substituted hydroxyapatite are the major components of a natural composite—bone tissue. Both of these materials also play a significant role in orthopedic surgery and implantology; however, their separate uses are limited; apatite is quite fragile, while collagen’s mechanical strength is very poor. Therefore, in biomaterial engineering, a combination of collagen and hydroxyapatite is used, which provides good mechanical properties with high biocompatibility and osteoinduction. In addition, the porous structure of the composites enables their use not only as bone defect fillers, but also as a drug release system providing controlled release of drugs directly to the bone. This feature makes biomimetic collagen–apatite composites a subject of research in many scientific centers. The review focuses on summarizing studies on biological activity, tested in vitro and in vivo.
Keywords: collagen; hydroxyapatite; biomimetic material; scaffold; bone regeneration; biocomposite collagen; hydroxyapatite; biomimetic material; scaffold; bone regeneration; biocomposite

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MDPI and ACS Style

Kołodziejska, B.; Kaflak, A.; Kolmas, J. Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review. Materials 2020, 13, 1748. https://doi.org/10.3390/ma13071748

AMA Style

Kołodziejska B, Kaflak A, Kolmas J. Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review. Materials. 2020; 13(7):1748. https://doi.org/10.3390/ma13071748

Chicago/Turabian Style

Kołodziejska, Barbara, Agnieszka Kaflak, and Joanna Kolmas. 2020. "Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review" Materials 13, no. 7: 1748. https://doi.org/10.3390/ma13071748

APA Style

Kołodziejska, B., Kaflak, A., & Kolmas, J. (2020). Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review. Materials, 13(7), 1748. https://doi.org/10.3390/ma13071748

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