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Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications
Open AccessArticle

Cuttlefish Bone-Derived Biphasic Calcium Phosphate Scaffolds Coated with Sol-Gel Derived Bioactive Glass

Department of Materials and Ceramic Engineering, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal
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Materials 2019, 12(17), 2711; https://doi.org/10.3390/ma12172711
Received: 15 July 2019 / Revised: 20 August 2019 / Accepted: 21 August 2019 / Published: 24 August 2019
(This article belongs to the Special Issue Scaffold Materials for Tissue Engineering)
The combination of calcium phosphates with bioactive glasses (BG) has received an increased interest in the field of bone tissue engineering. In the present work, biphasic calcium phosphates (BCP) obtained by hydrothermal transformation of cuttlefish bone (CB) were coated with a Sr-, Mg- and Zn-doped sol-gel derived BG. The scaffolds were characterized by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy. The initial CB structure was maintained after hydrothermal transformation (HT) and the scaffold functionalization did not jeopardize the internal structure. The results of the in-vitro bioactivity after immersing the BG coated scaffolds in simulated body fluid (SBF) for 15 days showed the formation of apatite on the surface of the scaffolds. Overall, the functionalized CB derived BCP scaffolds revealed promising properties, but further assessment of the in-vitro biological properties is needed before being considered for their use in bone tissue engineering applications. View Full-Text
Keywords: cuttlefish bone; biphasic calcium phosphate; porous scaffolds; sol-gel coatings; bioactivity; tissue engineering cuttlefish bone; biphasic calcium phosphate; porous scaffolds; sol-gel coatings; bioactivity; tissue engineering
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MDPI and ACS Style

Neto, A.S.; Brazete, D.; Ferreira, J.M. Cuttlefish Bone-Derived Biphasic Calcium Phosphate Scaffolds Coated with Sol-Gel Derived Bioactive Glass. Materials 2019, 12, 2711.

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