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Article

The Lebanese Red Algae Jania rubens: Promising Biomolecules against Colon Cancer Cells

by
Mariam Rifi
1,
Zeina Radwan
2,
Reem AlMonla
1,
Ziad Fajloun
1,3,
Jean Marc Sabatier
4,
Achraf Kouzayha
1,5,
Marwan El-Sabban
2,
Hiba Mawlawi
1,6,* and
Zeina Dassouki
1,3,*
1
Laboratory of Applied Biotechnology (LBA3B), AZM Center for Research in Biotechnology and its Applications, Doctoral School for Sciences and Technology, Lebanese University, Tripoli 1300, Lebanon
2
Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon
3
Department of Biology, Faculty of Sciences 3, Lebanese University, Campus Michel Slayman Ras Maska, Tripoli 1352, Lebanon
4
CNRS UMR 7051, INP, Inst. Neurophysiopathol., Aix-Marseille Université, 13385 Marseille, France
5
Department of Biochemistry, Faculty of Sciences 3, Lebanese University, Campus Michel Slayman Ras Maska, Tripoli 1352, Lebanon
6
Faculty of Public Health III, Lebanese University, Tripoli 1310, Lebanon
*
Authors to whom correspondence should be addressed.
Molecules 2022, 27(19), 6617; https://doi.org/10.3390/molecules27196617
Submission received: 4 September 2022 / Revised: 28 September 2022 / Accepted: 29 September 2022 / Published: 5 October 2022
(This article belongs to the Special Issue Anticancer Drug Discovery and Development II)
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Abstract

Colorectal cancer (CRC) is ranked the second most lethal type of tumor globally. Thus, developing novel anti-cancer therapeutics that are less aggressive and more potent is needed. Recently, natural bioactive molecules are gaining interest as complementary and supportive antineoplastic treatments due to their safety, effectiveness, and low cost. Jania rubens (J. rubens) is a red coral seaweed abundant in the Mediterranean and bears a significant pharmacological essence. Despite its therapeutic potential, the natural biomolecules extracted from this alga are poorly identified. In this study, the proximal analysis revealed high levels of total ash content (66%), 11.3% proteins, 14.5% carbohydrates, and only 4.5% lipids. The elemental identification showed magnesium and calcium were high among its macro minerals, (24 ± 0.5 mg/g) and (33 ± 0.5 mg/g), respectively. The Chlorophyll of J. rubens was dominated by other pigments with (0.82 ± 0.02 mg/g). A 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay identified effective antioxidant activity in various J. rubens extracts. More importantly, a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tetrazolium reduction and wound healing assays indicate that organic extracts from J. rubens significantly counteract the proliferation of colon cancer cell lines (HCT-116 and HT-29) and inhibit their migratory and metastatic properties in a dose and time-dependent manner. Overall, this study provides insight into the physicochemical properties of red seaweed, J. rubens, and identifies its significant antioxidant, cytotoxic, and anti-migratory potential on two colorectal cell lines, HCT-116 and HT-29.
Keywords: red algae; Jania rubens; biochemical analysis; antimicrobial; antioxidant; cytotoxic; human colon cancer cells red algae; Jania rubens; biochemical analysis; antimicrobial; antioxidant; cytotoxic; human colon cancer cells

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MDPI and ACS Style

Rifi, M.; Radwan, Z.; AlMonla, R.; Fajloun, Z.; Sabatier, J.M.; Kouzayha, A.; El-Sabban, M.; Mawlawi, H.; Dassouki, Z. The Lebanese Red Algae Jania rubens: Promising Biomolecules against Colon Cancer Cells. Molecules 2022, 27, 6617. https://doi.org/10.3390/molecules27196617

AMA Style

Rifi M, Radwan Z, AlMonla R, Fajloun Z, Sabatier JM, Kouzayha A, El-Sabban M, Mawlawi H, Dassouki Z. The Lebanese Red Algae Jania rubens: Promising Biomolecules against Colon Cancer Cells. Molecules. 2022; 27(19):6617. https://doi.org/10.3390/molecules27196617

Chicago/Turabian Style

Rifi, Mariam, Zeina Radwan, Reem AlMonla, Ziad Fajloun, Jean Marc Sabatier, Achraf Kouzayha, Marwan El-Sabban, Hiba Mawlawi, and Zeina Dassouki. 2022. "The Lebanese Red Algae Jania rubens: Promising Biomolecules against Colon Cancer Cells" Molecules 27, no. 19: 6617. https://doi.org/10.3390/molecules27196617

APA Style

Rifi, M., Radwan, Z., AlMonla, R., Fajloun, Z., Sabatier, J. M., Kouzayha, A., El-Sabban, M., Mawlawi, H., & Dassouki, Z. (2022). The Lebanese Red Algae Jania rubens: Promising Biomolecules against Colon Cancer Cells. Molecules, 27(19), 6617. https://doi.org/10.3390/molecules27196617

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