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Article

Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile

1
Department of Cardiologic, Vascular and Thoracic Sciences and Public Health, University of Padua, 35131 Padua, Italy
2
Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padua, 35131 Padua, Italy
3
Azienda Zero, Veneto Tumor Registry (RTV), 35131 Padua, Italy
4
Department of Statistical Sciences, University of Padua, 35131 Padua, Italy
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Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35131 Padua, Italy
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Hygiene and Public Health Service (SISP), Azienda ULSS 1 Dolomiti, 32100 Belluno, Italy
7
Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, 35131 Padua, Italy
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2022, 29(3), 2165-2173; https://doi.org/10.3390/curroncol29030175
Received: 3 February 2022 / Revised: 15 March 2022 / Accepted: 17 March 2022 / Published: 21 March 2022
(This article belongs to the Special Issue Epidemiology and Risk Factors of Skin Cancer)
Previous studies associated high-level exposure to ultraviolet radiation with a greater risk of cutaneous malignant melanoma (CMM). This study focuses on the changing incidence of CMM over time (from 1990 to 2017) in the Veneto region of Northeast Italy, and its Alpine area (the province of Belluno). The clinicopathological profile of CMM by residence is also considered. A joinpoint regression analysis was performed to identify significant changes in the yearly incidence of CMM by sex and age. For each trend, the average annual percent change (AAPC) was also calculated. In the 2017 CMM cohort, the study includes a descriptive analysis of the disease’s categorical clinicopathological variables. In the population investigated, the incidence of CMM has increased significantly over the last 30 years. The AAPC in the incidence of CMM was significantly higher among Alpine residents aged 0–49 than for the rest of the region’s population (males: 6.9 versus 2.4; females 7.7 versus 2.7, respectively). Among the Alpine residents, the AAPC was 3.35 times greater for females aged 0–49 than for people aged 50+. The clinicopathological profile of CMM was significantly associated with the place of residence. Over three decades, the Veneto population has observed a significant increase in the incidence of CMM, and its AAPC. Both trends have been markedly more pronounced among Alpine residents, particularly younger females. While epidemiology and clinicopathological profiles support the role of UV radiation in CMM, the young age of this CMM-affected female population points to other possible host-related etiological factors. These findings also confirm the importance of primary and secondary prevention strategies. View Full-Text
Keywords: melanoma; incidence; joinpoint; mountain residents; ultraviolet radiation; UVR; spatial analysis; temporal trends; sun exposure melanoma; incidence; joinpoint; mountain residents; ultraviolet radiation; UVR; spatial analysis; temporal trends; sun exposure
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MDPI and ACS Style

Buja, A.; Rugge, M.; De Luca, G.; Bovo, E.; Zorzi, M.; De Toni, C.; Cozzolino, C.; Vecchiato, A.; Del Fiore, P.; Spina, R.; Cinquetti, S.; Baldo, V.; Rossi, C.R.; Mocellin, S. Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile. Curr. Oncol. 2022, 29, 2165-2173. https://doi.org/10.3390/curroncol29030175

AMA Style

Buja A, Rugge M, De Luca G, Bovo E, Zorzi M, De Toni C, Cozzolino C, Vecchiato A, Del Fiore P, Spina R, Cinquetti S, Baldo V, Rossi CR, Mocellin S. Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile. Current Oncology. 2022; 29(3):2165-2173. https://doi.org/10.3390/curroncol29030175

Chicago/Turabian Style

Buja, Alessandra, Massimo Rugge, Giuseppe De Luca, Emanuela Bovo, Manuel Zorzi, Chiara De Toni, Claudia Cozzolino, Antonella Vecchiato, Paolo Del Fiore, Romina Spina, Sandro Cinquetti, Vincenzo Baldo, Carlo Riccardo Rossi, and Simone Mocellin. 2022. "Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile" Current Oncology 29, no. 3: 2165-2173. https://doi.org/10.3390/curroncol29030175

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