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Current Oncology
Volume 29
Issue 1
10.3390/curroncol29010003
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Article

Prospective Randomized Phase II Study of Stereotactic Body Radiotherapy (SBRT) vs. Conventional Fractionated Radiotherapy (CFRT) for Chinese Patients with Early-Stage Localized Prostate Cancer †

by
Darren M. C. Poon
1,2,*,
Daisy Lam
1,
Kenneth C. W. Wong
1,
Cheuk-Man Chu
3,
Michael Cheung
1,
Frankie Mo
1,
Joyce Suen
1,
Chi-Fai Ng
4 and
Anthony T. C. Chan
1
1
Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
2
Comprehensive Oncology Centre, Hong Kong Sanatorium & Hospital, Hong Kong, China
3
Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
4
Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
*
Author to whom correspondence should be addressed.
†
Presentations: Presented in part at the 2019 Asian Congress of European Society of Medical Oncology, Singapore, 23–25 November 2018, and at the 2019 American Society of Clinical Oncology Genitourinary Symposium, San Francisco, CA, USA, 14–16 February 2019.
Curr. Oncol. 2022, 29(1), 27-37; https://doi.org/10.3390/curroncol29010003
Submission received: 24 November 2021 / Revised: 17 December 2021 / Accepted: 19 December 2021 / Published: 22 December 2021
(This article belongs to the Collection New Insights into Prostate Cancer Diagnosis and Treatment)
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Abstract

Background: Stereotactic body radiotherapy (SBRT) has potential radiobiologic and economic advantages over conventional fractionated radiotherapy (CFRT) in localized prostate cancer (PC). This study aimed to compare the effects of these two distinct fractionations on patient-reported quality of life (PRQOL) and tolerability. Methods: In this prospective phase II study, patients with low- and intermediate-risk localized PC were randomly assigned in a 1:1 ratio to the SBRT (36.25 Gy/5 fractions/2 weeks) or CFRT (76 Gy/38 fractions/7.5 weeks) treatment groups. The primary endpoint of variation in PRQOL at 1 year was assessed by changes in the Expanded Prostate Cancer Index Composite (EPIC) questionnaire scores and analysed by z-tests and t-tests. Results: Sixty-four eligible Chinese men were treated (SBRT, n = 31; CFRT, n = 33) with a median follow-up of 2.3 years. At 1 year, 40.0%/46.9% of SBRT/CFRT patients had a >5-point decrease in bowel score (p = 0.08/0.28), respectively, and 53.3%/46.9% had a >2-point decrease in urinary score (p = 0.21/0.07). There were no significant differences in EPIC score changes between the arms at 3, 6, 9 and 12 months, but SBRT was associated with significantly fewer grade ≥ 1 acute and 1-year late gastrointestinal toxicities (acute: 35% vs. 87%, p < 0.0001; 1-year late: 64% vs. 84%, p = 0.03), and grade ≥ 2 acute genitourinary toxicities (3% vs. 24%, p = 0.04) compared with CFRT. Conclusion: SBRT offered similar PRQOL and less toxicity compared with CFRT in Chinese men with localized PC.
Keywords: dose fractionation (radiation); patient reported outcomes; prostate cancer; quality of life; radiation tolerance; stereotactic body radiotherapy dose fractionation (radiation); patient reported outcomes; prostate cancer; quality of life; radiation tolerance; stereotactic body radiotherapy

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MDPI and ACS Style

Poon, D.M.C.; Lam, D.; Wong, K.C.W.; Chu, C.-M.; Cheung, M.; Mo, F.; Suen, J.; Ng, C.-F.; Chan, A.T.C. Prospective Randomized Phase II Study of Stereotactic Body Radiotherapy (SBRT) vs. Conventional Fractionated Radiotherapy (CFRT) for Chinese Patients with Early-Stage Localized Prostate Cancer. Curr. Oncol. 2022, 29, 27-37. https://doi.org/10.3390/curroncol29010003

AMA Style

Poon DMC, Lam D, Wong KCW, Chu C-M, Cheung M, Mo F, Suen J, Ng C-F, Chan ATC. Prospective Randomized Phase II Study of Stereotactic Body Radiotherapy (SBRT) vs. Conventional Fractionated Radiotherapy (CFRT) for Chinese Patients with Early-Stage Localized Prostate Cancer. Current Oncology. 2022; 29(1):27-37. https://doi.org/10.3390/curroncol29010003

Chicago/Turabian Style

Poon, Darren M. C., Daisy Lam, Kenneth C. W. Wong, Cheuk-Man Chu, Michael Cheung, Frankie Mo, Joyce Suen, Chi-Fai Ng, and Anthony T. C. Chan. 2022. "Prospective Randomized Phase II Study of Stereotactic Body Radiotherapy (SBRT) vs. Conventional Fractionated Radiotherapy (CFRT) for Chinese Patients with Early-Stage Localized Prostate Cancer" Current Oncology 29, no. 1: 27-37. https://doi.org/10.3390/curroncol29010003

APA Style

Poon, D. M. C., Lam, D., Wong, K. C. W., Chu, C.-M., Cheung, M., Mo, F., Suen, J., Ng, C.-F., & Chan, A. T. C. (2022). Prospective Randomized Phase II Study of Stereotactic Body Radiotherapy (SBRT) vs. Conventional Fractionated Radiotherapy (CFRT) for Chinese Patients with Early-Stage Localized Prostate Cancer. Current Oncology, 29(1), 27-37. https://doi.org/10.3390/curroncol29010003

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