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Cardiovasc. Med., Volume 21, Issue 7-8 (08 2018) – 4 articles

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2 pages, 225 KB

Open AccessInteresting Images

Thrombus in Transit

by Haseeb Nawaz, Thomas Zach, Bhatti Karan, Hariri Imad and Idris Owais

Cardiovasc. Med. 2018, 21(7-8), 200; https://doi.org/10.4414/cvm.2018.00572 - 7 Aug 2018

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Abstract

An 88-year-old man with a history of transient ischaemic attack, chronic kidney disease and primary hypertension presented with dyspnoea and was found to have large bilateral pulmonary emboli on a computedtomography angiogram of the chest [...] Full article

5 pages, 170 KB

Open AccessEditorial

New Compounds for the Treatment of Pulmonary Hypertension

by Roger Hullin

Cardiovasc. Med. 2018, 21(7-8), 195; https://doi.org/10.4414/cvm.2018.00556 - 7 Aug 2018

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Abstract

Survival with pulmonary arterial hypertension has significantly improved in the last two decades with the development and approval of different compounds. This review highlights the properties of molecules that more recently became available for specific treatment of pulmonary hypertension. Full article

4 pages, 434 KB

Open AccessReview

A Shunt Device to Reduce Left Atrial Pressure

by Gerd Hasenfuss, Daniel Burkhoff and David M. Kaye

Cardiovasc. Med. 2018, 21(7-8), 191; https://doi.org/10.4414/cvm.2018.00568 - 7 Aug 2018

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Abstract

Reducing pulmonary artery pressure with the IASD may be a new therapeutic option to treat symptomatic heart failure patients with preserved or moderately reduced ejection fraction [...] Full article

10 pages, 463 KB

Open AccessReview

Instantaneous Wave-Free Ratio: An Adenosine-Independent Index to Guide Coronary Revascularisation

by Juan F. Iglesias, Sophie Degrauwe, Yousif Ahmadc, Sukhjinder S. Nijjer, Justin E. Davies and Sayan Sen

Cardiovasc. Med. 2018, 21(7-8), 181; https://doi.org/10.4414/cvm.2018.00566 - 7 Aug 2018

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Abstract

The use of coronary physiology to guide myocardial revascularisation was shown to improve clinical outcomes and reduce costs in patients with coronary artery disease. Fractional flow reserve (FFR) is the most commonly used pressure-derived physiological index for coronary lesion assessment, being supported by a body of compelling randomised evidence, but its uptake into clinical practice remains unacceptably low. The instantaneous wave-free ratio (iFR) is a novel adenosine-free pressurederived index of coronary stenosis severity that was recently introduced to circumvent the limitations of existing hyperaemic pressure-derived indices with the aim of increasing the widespread adoption of coronary physiology assessment. Following the recent publication of two large-scale, randomised, patient outcome clinical trials, iFR has emerged as a simpler, safe and effective alternative to FFR to guide coronary revascularisation. This has led to renewed interest in the field of coronary physiology and challenges current paradigms supporting the need for pharmacologically-induced maximal hyperaemia as an essential requirement for coronary stenosis assessment. This review aims at addressing the physiological concepts and patient outcome evidence supporting the use of iFR and discuss the recent development of novel iFR-based applications allowing full integration of invasive coronary physiology in percutaneous coronary intervention planning strategy. Full article

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Cardiovasc. Med., Volume 21, Issue 7-8 (08 2018) – 4 articles

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