Exploring the Pharmacological Landscape of Undaria pinnatifida: Insights into Neuroprotective Actions and Bioactive Constituents
Abstract
1. Introduction
2. U. pinnatifida Compounds and Applications
2.1. U. pinnatifida Polysaccharides
2.1.1. Fucoidan (Figure 1)
2.1.2. Alginates (Figure 3)
2.2. Pharmacological Activities of U. pinnatifida Polysaccharides
2.2.1. Anti-Angiogenic Activity
2.2.2. Anti-Tumor Activity
2.2.3. Antihypertension
2.2.4. Anti-Inflammatory Activity
2.2.5. Antioxidant Activity
2.2.6. Immunomodulatory Activity
2.2.7. Antiviral and Antibacterial Activity
2.2.8. Anticoagulating and Antithrombotic Activities
2.2.9. Renoprotective Activities
2.3. U. pinnatifida Non-Polysaccharide Compounds and Their Pharmacological Applications
2.3.1. Fucoxanthin
2.3.2. Fucoesterols
2.3.3. Phenolic Compounds—Flavonoids and Phlorotannins
3. Focus on the Neuroprotective Actions of U. pinnatifida: Mechanisms and Key Compounds
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Bioactive Compounds of U. pinnatifida | Bioactivities | Possible Mechanisms | References |
---|---|---|---|
Fucoidan | Anti-angiogenic |
| [48] |
Anti-tumour |
| [3,50,51,52,54] | |
Hypertension prevention |
| [3,61] | |
Anti-coagulant and anti-thrombosis |
| [3,80,81,82] | |
Anti-inflammatory and immunomodulation |
| [3,28,62,63,69,70,71,72,74] | |
Anti-oxidant |
| [26,63,67,73] | |
Anti-microorganisms |
| [3,25,76,78,79,85] | |
Neuroprotective |
| [27,85,86,87,88,89,90,91,92,93] | |
Glycoproteins (UPGP) | Neuroprotective |
| [92] |
Fucoxanthin | Anti-obesity |
| [94,95,96] |
Neuroprotective |
| [9,96,97,98] | |
Alginates | Anti-obesity |
| [42,43] |
Fucosterol | Neuroprotective |
| [11,99,100] |
Phenolic compounds | Antioxidant |
| [39,101,102,103] |
Anti-obesity |
| [104] |
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Machado, H.; Machado, J.P.; Alves, C.; Soares, C.; Grosso, C.; Rodrigues, J.M.; Criado, M.B. Exploring the Pharmacological Landscape of Undaria pinnatifida: Insights into Neuroprotective Actions and Bioactive Constituents. Nutraceuticals 2025, 5, 20. https://doi.org/10.3390/nutraceuticals5030020
Machado H, Machado JP, Alves C, Soares C, Grosso C, Rodrigues JM, Criado MB. Exploring the Pharmacological Landscape of Undaria pinnatifida: Insights into Neuroprotective Actions and Bioactive Constituents. Nutraceuticals. 2025; 5(3):20. https://doi.org/10.3390/nutraceuticals5030020
Chicago/Turabian StyleMachado, Helena, Jorge Pereira Machado, Christian Alves, Cristina Soares, Clara Grosso, Jorge Magalhães Rodrigues, and Maria Begoña Criado. 2025. "Exploring the Pharmacological Landscape of Undaria pinnatifida: Insights into Neuroprotective Actions and Bioactive Constituents" Nutraceuticals 5, no. 3: 20. https://doi.org/10.3390/nutraceuticals5030020
APA StyleMachado, H., Machado, J. P., Alves, C., Soares, C., Grosso, C., Rodrigues, J. M., & Criado, M. B. (2025). Exploring the Pharmacological Landscape of Undaria pinnatifida: Insights into Neuroprotective Actions and Bioactive Constituents. Nutraceuticals, 5(3), 20. https://doi.org/10.3390/nutraceuticals5030020