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Article

Biomonitoring of Phthalates, Bisphenols and Parabens in Children: Exposure, Predictors and Risk Assessment

by
Pablo Dualde
1,
Nuria León
2,
Yovana Sanchis
2,
Francisca Corpas-Burgos
1,
Sandra F. Fernández
1,
Cristina S. Hernández
1,
Guillermo Saez
3,
Erika Pérez-Zafra
3,
Antonio Mora-Herranz
3,
Olga Pardo
1,4,
Clara Coscollà
1,
Antonio López
1,
Vicent Yusà
1,2,4,* and
on behalf of the BIOVAL Task Force
†
1
Foundation for the Promotion of Health and Biomedical Research of the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
2
Public Health Laboratory of Valencia, Av. Cataluña, 21, 46020 Valencia, Spain
3
Conselleria Sanitat, Universitary Hospital Doctor Peset, Av. Gaspar Aguilar, 90, 46017 Valencia, Spain
4
Analytical Chemistry Department, University of Valencia, Edifici Jeroni Muñoz, Dr. Moliner 50, 46100 Burjassot, Spain
*
Author to whom correspondence should be addressed.
†
Membership of the BIOVAL Task Force is provided in the Acknowledgments.
Int. J. Environ. Res. Public Health 2021, 18(17), 8909; https://doi.org/10.3390/ijerph18178909
Submission received: 25 June 2021 / Revised: 10 August 2021 / Accepted: 21 August 2021 / Published: 24 August 2021
(This article belongs to the Special Issue New Threads in Environmental Toxicology)
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Abstract

Exposure to emerging contaminants, such as phthalates, bisphenols and parabens in children has been associated with possible neurodevelopment and endocrine alterations. In the present study, the biomonitoring of biomarkers in children (5–12 years old) from the Valencia Region (Spain) have been implemented using urines from the BIOVAL program. More than 75% of the children studied (n = 562) were internally exposed (>LOQ) to bisphenols and parabens, and the whole population assessed (n = 557) were exposed to at least one phthalate. The geometric means (GM) of the concentrations of bisphenol A, methyl paraben and propyl paraben were 0.9, 1.4 and 0.39 ng/mL, respectively. Regarding phthalates, monoethyl phthalate GM was 55.0 ng/mL and diethyl hexyl phthalate (as the sum of five metabolites) GM was 60.6 ng/mL. Despite the studied population being widely exposed, the detection frequencies and concentrations were in general lower than in previous studies involving children in Spain and in other countries in recent years. Furthermore, the risk assessment study concluded that the internal exposure to phthalates, bisphenols and parabens is lower than the guidance values established, and, therefore, a health risk derived from the exposure to these compounds in the studied population is not expected.
Keywords: biomonitoring; phthalates; bisphenols; parabens; urine; risk assessment biomonitoring; phthalates; bisphenols; parabens; urine; risk assessment

Share and Cite

MDPI and ACS Style

Dualde, P.; León, N.; Sanchis, Y.; Corpas-Burgos, F.; Fernández, S.F.; Hernández, C.S.; Saez, G.; Pérez-Zafra, E.; Mora-Herranz, A.; Pardo, O.; et al. Biomonitoring of Phthalates, Bisphenols and Parabens in Children: Exposure, Predictors and Risk Assessment. Int. J. Environ. Res. Public Health 2021, 18, 8909. https://doi.org/10.3390/ijerph18178909

AMA Style

Dualde P, León N, Sanchis Y, Corpas-Burgos F, Fernández SF, Hernández CS, Saez G, Pérez-Zafra E, Mora-Herranz A, Pardo O, et al. Biomonitoring of Phthalates, Bisphenols and Parabens in Children: Exposure, Predictors and Risk Assessment. International Journal of Environmental Research and Public Health. 2021; 18(17):8909. https://doi.org/10.3390/ijerph18178909

Chicago/Turabian Style

Dualde, Pablo, Nuria León, Yovana Sanchis, Francisca Corpas-Burgos, Sandra F. Fernández, Cristina S. Hernández, Guillermo Saez, Erika Pérez-Zafra, Antonio Mora-Herranz, Olga Pardo, and et al. 2021. "Biomonitoring of Phthalates, Bisphenols and Parabens in Children: Exposure, Predictors and Risk Assessment" International Journal of Environmental Research and Public Health 18, no. 17: 8909. https://doi.org/10.3390/ijerph18178909

APA Style

Dualde, P., León, N., Sanchis, Y., Corpas-Burgos, F., Fernández, S. F., Hernández, C. S., Saez, G., Pérez-Zafra, E., Mora-Herranz, A., Pardo, O., Coscollà, C., López, A., Yusà, V., & on behalf of the BIOVAL Task Force. (2021). Biomonitoring of Phthalates, Bisphenols and Parabens in Children: Exposure, Predictors and Risk Assessment. International Journal of Environmental Research and Public Health, 18(17), 8909. https://doi.org/10.3390/ijerph18178909

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