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Marine Drugs
Volume 21
Issue 12
10.3390/md21120607
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Article

A Novel Anticancer Peptide Derived from Bryopsis plumosa Regulates Proliferation and Invasion in Non-Small Cell Lung Cancer Cells

by
Heabin Kim
1,†,
Hyun-Taek Kim
2,†,
Seung-Hyun Jung
1,
Jong Won Han
1,
Seonmi Jo
1,
In-Gyu Kim
3,
Rae-Kwon Kim
3,4,
Yeon-Jee Kahm
3,4,
Tae-Ik Choi
5,
Cheol-Hee Kim
5 and
Jei Ha Lee
1,*
1
Department of Genetic Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Republic of Korea
2
Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan-si 31151, Republic of Korea
3
Department of Radiation Biology, Environmental Safety Assessment Research Division, Korea Atomic Energy Research Institute, Daejeon 34057, Republic of Korea
4
Department of Radiation Science and Technology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea
5
Department of Biology, Chungnam National University, Yuseong-gu, Daejeon 34134, Republic of Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Mar. Drugs 2023, 21(12), 607; https://doi.org/10.3390/md21120607
Submission received: 13 October 2023 / Revised: 21 November 2023 / Accepted: 23 November 2023 / Published: 24 November 2023
(This article belongs to the Collection Marine Compounds and Cancer)
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Abstract

The discovery of new highly effective anticancer drugs with few side effects is a challenge for drug development research. Natural or synthetic anticancer peptides (ACPs) represent a new generation of anticancer agents with high selectivity and specificity. The rapid emergence of chemoradiation-resistant lung cancer has necessitated the discovery of novel anticancer agents as alternatives to conventional therapeutics. In this study, we synthesized a peptide containing 22 amino acids and characterized it as a novel ACP (MP06) derived from green sea algae, Bryopsis plumosa. Using the ACP database, MP06 was predicted to possess an alpha-helical secondary structure and functionality. The anti-proliferative and apoptotic effects of the MP06, determined using the cytotoxicity assay and Annexin V/propidium iodide staining kit, were significantly higher in non-small-cell lung cancer (NSCLC) cells than in non-cancerous lung cells. We confirmed that MP06 suppressed cellular migration and invasion and inhibited the expression of N-cadherin and vimentin, the markers of epithelial–mesenchymal transition. Moreover, MP06 effectively reduced the metastasis of tumor xenografts in zebrafish embryos. In conclusion, we suggest considering MP06 as a novel candidate for the development of new anticancer drugs functioning via the ERK signaling pathway.
Keywords: Bryopsis plumose; anticancer peptide; EMT; NSCLC; cancer Bryopsis plumose; anticancer peptide; EMT; NSCLC; cancer

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MDPI and ACS Style

Kim, H.; Kim, H.-T.; Jung, S.-H.; Han, J.W.; Jo, S.; Kim, I.-G.; Kim, R.-K.; Kahm, Y.-J.; Choi, T.-I.; Kim, C.-H.; et al. A Novel Anticancer Peptide Derived from Bryopsis plumosa Regulates Proliferation and Invasion in Non-Small Cell Lung Cancer Cells. Mar. Drugs 2023, 21, 607. https://doi.org/10.3390/md21120607

AMA Style

Kim H, Kim H-T, Jung S-H, Han JW, Jo S, Kim I-G, Kim R-K, Kahm Y-J, Choi T-I, Kim C-H, et al. A Novel Anticancer Peptide Derived from Bryopsis plumosa Regulates Proliferation and Invasion in Non-Small Cell Lung Cancer Cells. Marine Drugs. 2023; 21(12):607. https://doi.org/10.3390/md21120607

Chicago/Turabian Style

Kim, Heabin, Hyun-Taek Kim, Seung-Hyun Jung, Jong Won Han, Seonmi Jo, In-Gyu Kim, Rae-Kwon Kim, Yeon-Jee Kahm, Tae-Ik Choi, Cheol-Hee Kim, and et al. 2023. "A Novel Anticancer Peptide Derived from Bryopsis plumosa Regulates Proliferation and Invasion in Non-Small Cell Lung Cancer Cells" Marine Drugs 21, no. 12: 607. https://doi.org/10.3390/md21120607

APA Style

Kim, H., Kim, H.-T., Jung, S.-H., Han, J. W., Jo, S., Kim, I.-G., Kim, R.-K., Kahm, Y.-J., Choi, T.-I., Kim, C.-H., & Lee, J. H. (2023). A Novel Anticancer Peptide Derived from Bryopsis plumosa Regulates Proliferation and Invasion in Non-Small Cell Lung Cancer Cells. Marine Drugs, 21(12), 607. https://doi.org/10.3390/md21120607

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