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Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9-cis-β-Carotene from Dunaliella salina

1
Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK
2
School of Science, University of Greenwich, Central Avenue, Chatham ME4 4TB, UK
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 279; https://doi.org/10.3390/md17050279
Received: 5 April 2019 / Revised: 1 May 2019 / Accepted: 8 May 2019 / Published: 10 May 2019
(This article belongs to the Special Issue Anti-Photoagaing and Photo-Protective Compounds from Marine Organisms)
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Abstract

Carotenoids are implicated in alleviating ageing and age-related diseases in humans. While data from different carotenoids are mixed in their outcomes, those for 9-cis-β-carotene indicate general positive effects, although basic data on its biological impact are limited. Here, we show that supplementation with 9-cis-β-carotene in ageing Drosophila melanogaster improved mitochondrial function in terms of ATP production and whole-body respiration and extended mean lifespan. It also resulted in improved mobility. These data provide a potential biological rational for the beneficial effects of dietary supplementation with 9-cis-β-carotene. These effects may be based on the maintenance of a sound mitochondrial function. View Full-Text
Keywords: ageing; 9-cis-β-carotene; mitochondrial function; mobility; lifespan; Drosophila melanogaster; microalgae; Dunaliella salina ageing; 9-cis-β-carotene; mitochondrial function; mobility; lifespan; Drosophila melanogaster; microalgae; Dunaliella salina
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Weinrich, T.; Xu, Y.; Wosu, C.; Harvey, P.J.; Jeffery, G. Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9-cis-β-Carotene from Dunaliella salina. Mar. Drugs 2019, 17, 279.

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