Next Article in Journal
9-Methylfascaplysin Is a More Potent Aβ Aggregation Inhibitor than the Marine-Derived Alkaloid, Fascaplysin, and Produces Nanomolar Neuroprotective Effects in SH-SY5Y Cells
Next Article in Special Issue
Soritesidine, a Novel Proteinous Toxin from the Okinawan Marine Sponge Spongosorites sp.
Previous Article in Journal
Biosynthesis of Nutraceutical Fatty Acids by the Oleaginous Marine Microalgae Phaeodactylum tricornutum Utilizing Hydrolysates from Organosolv-Pretreated Birch and Spruce Biomass
Previous Article in Special Issue
Cacolides: Sesterterpene Butenolides from a Southern Australian Marine Sponge, Cacospongia sp.
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle

Briarenones A‒C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
3
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
4
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
5
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
7
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(2), 120; https://doi.org/10.3390/md17020120
Received: 9 January 2019 / Revised: 1 February 2019 / Accepted: 12 February 2019 / Published: 17 February 2019
(This article belongs to the Special Issue Marine Natural Products Discovery: In Honor of Late Prof. Tatsuo Higa)
  |  
PDF [1626 KB, uploaded 18 February 2019]
  |     |  

Abstract

Three new eunicellin-derived diterpenoids of briarellin type, briarenones A‒C (13), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR. The absolute configuration of 1 was further confirmed by a single crystal X-ray diffraction analysis. The in vitro cytotoxic and anti-inflammatory potentialities of the isolated metabolites were tested against the growth of a limited panel of cancer cell lines and against the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenyl-alanine and cytochalasin B (fMLF/CB)-stimulated human neutrophils, respectively. View Full-Text
Keywords: Briareum violaceum; briarenones; briarellin; gorgonian Briareum violaceum; briarenones; briarellin; gorgonian
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Cheng, Y.; Ahmed, A.F.; Orfali, R.S.; Dai, C.-F.; Sheu, J.-H. Briarenones A‒C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum. Mar. Drugs 2019, 17, 120.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top