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Briarenones A‒C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(2), 120;
Received: 9 January 2019 / Revised: 1 February 2019 / Accepted: 12 February 2019 / Published: 17 February 2019
(This article belongs to the Special Issue Marine Natural Products Discovery: In Honor of Late Prof. Tatsuo Higa)
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Three new eunicellin-derived diterpenoids of briarellin type, briarenones A‒C (13), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR. The absolute configuration of 1 was further confirmed by a single crystal X-ray diffraction analysis. The in vitro cytotoxic and anti-inflammatory potentialities of the isolated metabolites were tested against the growth of a limited panel of cancer cell lines and against the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenyl-alanine and cytochalasin B (fMLF/CB)-stimulated human neutrophils, respectively. View Full-Text
Keywords: Briareum violaceum; briarenones; briarellin; gorgonian Briareum violaceum; briarenones; briarellin; gorgonian

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Cheng, Y.; Ahmed, A.F.; Orfali, R.S.; Dai, C.-F.; Sheu, J.-H. Briarenones A‒C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum. Mar. Drugs 2019, 17, 120.

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