Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518

Liu, Hai-Li; E, Heng-Chao; Xie, Ding-An; Cheng, Wen-Bo; Tao, Wan-Qi; Wang, Yong

doi:10.3390/md16110403

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Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518

by

Hai-Li Liu

^1,2,†,

Heng-Chao E

^1,2,†,

Ding-An Xie

³,

Wen-Bo Cheng

^1,2,

Wan-Qi Tao

⁴ and

Yong Wang

^1,2,*

¹

Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China

²

University of Chinese Academy of Sciences, Beijing 100039, China

³

College of Food Science and Engineering, Ocean University of China, Shanghai 201306, China

⁴

School of Life Sciences, University of Liverpool, Liverpool L69 3BX, UK

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally.

Mar. Drugs 2018, 16(11), 403; https://doi.org/10.3390/md16110403

Submission received: 4 August 2018 / Revised: 17 October 2018 / Accepted: 20 October 2018 / Published: 23 October 2018

(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)

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Abstract

Five new acylated aminooligosaccharides (1–5), together with one known related analogue (6), were isolated from Streptomyces sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with those reported in the literature. All of the new compounds showed more promising porcine pancreatic α-amylase (PPA) inhibitory activities than the clinical drug acarbose, indicating them as potential pharmaceutical drug leads toward type II diabetes.

Keywords: Streptomyces sp. HO1518; acylated aminooligosaccharides; porcine pancreatic α-amylase (PPA) inhibitor

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MDPI and ACS Style

Liu, H.-L.; E, H.-C.; Xie, D.-A.; Cheng, W.-B.; Tao, W.-Q.; Wang, Y. Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518. Mar. Drugs 2018, 16, 403. https://doi.org/10.3390/md16110403

AMA Style

Liu H-L, E H-C, Xie D-A, Cheng W-B, Tao W-Q, Wang Y. Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518. Marine Drugs. 2018; 16(11):403. https://doi.org/10.3390/md16110403

Chicago/Turabian Style

Liu, Hai-Li, Heng-Chao E, Ding-An Xie, Wen-Bo Cheng, Wan-Qi Tao, and Yong Wang. 2018. "Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518" Marine Drugs 16, no. 11: 403. https://doi.org/10.3390/md16110403

APA Style

Liu, H.-L., E, H.-C., Xie, D.-A., Cheng, W.-B., Tao, W.-Q., & Wang, Y. (2018). Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518. Marine Drugs, 16(11), 403. https://doi.org/10.3390/md16110403

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Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518

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