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Mar. Drugs 2018, 16(11), 404; https://doi.org/10.3390/md16110404

Components from the Leaves and Twigs of Mangrove Lumnitzera racemosa with Anti-Angiogenic and Anti-Inflammatory Effects

1
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan
3
Graduate Institute of Natural Products, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
4
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
5
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
6
Department of Life Science, National Taitung University, Taitung 950, Taiwan
7
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan
8
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 5 October 2018 / Revised: 20 October 2018 / Accepted: 23 October 2018 / Published: 25 October 2018
(This article belongs to the Special Issue Development and Application of Herbal Medicine from Marine Origin)
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Abstract

One new neolignan, racelactone A (1), together with seven known compounds (28) were isolated from the methanolic extract of the leaves and twigs of Lumnitzera racemosa. The structure of racelactone A (1) was determined on the basis of the mass and NMR spectroscopic data interpretation. With respect to bioactivity, compound 1 displayed an anti-angiogenic effect by suppressing tube formation. Furthermore, compounds 1, 4, and 5 showed significant anti-inflammatory effects with IC50 values of 4.95 ± 0.89, 1.95 ± 0.40, and 2.57 ± 0.23 μM, respectively. The plausible biosynthesis pathway of racelactone A (1) was proposed. View Full-Text
Keywords: neolignan; Lumnitzera racemosa; anti-angiogenesis; anti-inflammation neolignan; Lumnitzera racemosa; anti-angiogenesis; anti-inflammation
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Yu, S.-Y.; Wang, S.-W.; Hwang, T.-L.; Wei, B.-L.; Su, C.-J.; Chang, F.-R.; Cheng, Y.-B. Components from the Leaves and Twigs of Mangrove Lumnitzera racemosa with Anti-Angiogenic and Anti-Inflammatory Effects. Mar. Drugs 2018, 16, 404.

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