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Mar. Drugs 2017, 15(12), 382;

Terpenoids from Octocorals of the Genus Pachyclavularia

1,2,3,4, 4,*, 5,6,7,* and 1,4,5,8,9,*
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Greenhouse Systems Technology Center, Central Region Campus, Industrial Technology Research Institute, Nantou 540, Taiwan
Forcean Marine International Corporation, Kaohsiung 800, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Authors to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 1 December 2017 / Accepted: 4 December 2017 / Published: 5 December 2017
(This article belongs to the Special Issue Development and Application of Herbal Medicine from Marine Origin)
PDF [3573 KB, uploaded 5 December 2017]


In this paper, we reviewed natural compounds isolated from octocorals belonging to the genus Pachyclavularia, including 20 cembrane-, 39 briarane-, and eight briarellin-related diterpenoids, and one secosterol. The chemical constituents of these 68 secondary metabolites, and their names, structures, and bioactivities, along with studies of their biological activities, are summarized in this review. Based on the literature, many of these compounds possess bioactivities, including anti-inflammation properties, cytotoxicity, and ichthyotoxicity, suggesting that they may have the potential to be developed into biomedical agents for treatment. View Full-Text
Keywords: Pachyclavularia; octocoral; cembrane; briarane; briarellin; secosterol; bioactivity Pachyclavularia; octocoral; cembrane; briarane; briarellin; secosterol; bioactivity

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Chang, Y.-C.; Sheu, J.-H.; Wu, Y.-C.; Sung, P.-J. Terpenoids from Octocorals of the Genus Pachyclavularia. Mar. Drugs 2017, 15, 382.

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