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Eight New Peptaibols from Sponge-Associated Trichoderma atroviride

Raymond and Beverly Sackler School of Chemistry and Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel
Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
Department of Plant Pathology and Microbiology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Author to whom correspondence should be addressed.
Mar. Drugs 2013, 11(12), 4937-4960;
Received: 24 September 2013 / Revised: 28 October 2013 / Accepted: 11 November 2013 / Published: 11 December 2013
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Eight new and four known peptaibols were isolated from a strain of the fungus, Trichoderma atroviride (NF16), which was cultured from an Axinellid sponge collected from the East Mediterranean coast of Israel. The structures of the pure compounds were determined using HRMS, MS/MS and one- and two-dimensional NMR measurements. The isolated compounds belong to the trichorzianines, a family of 19-residue linear hydrophobic peptides containing a high proportion of α-aminoisobutyric acid (Aib), an acetylated N-terminus and a C-terminal amino alcohol. These new peptaibols exhibited antimicrobial activity against environmental bacteria isolated from the Mediterranean coast of Israel. View Full-Text
Keywords: peptaibols; trichorzianines; Trichoderma atroviride; Axinella polypoides; Axinella verrucosa peptaibols; trichorzianines; Trichoderma atroviride; Axinella polypoides; Axinella verrucosa

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Panizel, I.; Yarden, O.; Ilan, M.; Carmeli, S. Eight New Peptaibols from Sponge-Associated Trichoderma atroviride. Mar. Drugs 2013, 11, 4937-4960.

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