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Volume 58
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Review

Up-to-Date Procedures in Female Stress Urinary Incontinence Surgery: A Concise Review on Bulking Agents Procedures

by
Maurizio Serati
1,*,†,
Andrea Braga
2,3,
Stefano Salvatore
4,
Marco Torella
5,
Maria Carmela Di Dedda
6,
Chiara Scancarello
1,
Chiara Cimmino
1,
Andrea De Rosa
1,
Matteo Frigerio
7,
Massimo Candiani
4 and
Alessandro Ferdinando Ruffolo
4
1
Department of Obstetrics and Gynecology, Del Ponte Hospital, University of Insubria, 21100 Varese, Italy
2
Department of Obstetrics and Gynecology, EOC—Beata Vergine Hospital, 6850 Mendrisio, Switzerland
3
Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, Switzerland
4
Obstetrics and Gynecology Unit, IRCCS San Raffaele Hospital, Vita-Salute University, 20132 Milano, Italy
5
Department of Obstetrics and Gynecology, Second Faculty, 80129 Naples, Italy
6
Department of Obstetrics and Gynecology, ASST FBF-SACCO Macedonio Melloni Hospital, 20129 Milano, Italy
7
ASST Monza, Ospedale San Gerardo, 20900 Monza, Italy
*
Author to whom correspondence should be addressed.
†
President of European Urgynaecological Association (EUGA).
Medicina 2022, 58(6), 775; https://doi.org/10.3390/medicina58060775
Submission received: 11 May 2022 / Revised: 1 June 2022 / Accepted: 6 June 2022 / Published: 8 June 2022
(This article belongs to the Section Obstetrics and Gynecology)
Review Reports Versions Notes

Abstract

To avoid complications related to mid-urethral slings (MUS), alternative procedures to treat stress urinary incontinence (SUI), such as urethral bulking agents (UBAs) have been adopted. The aim of this review is to narratively report the efficacy and safety of UBAs for SUI treatment. For this review, research from PubMed and EMBASE was performed to evaluate relevant studies that were undertaken from January 2012 to January 2022. Nineteen prospective studies were included. Several definitions of subjective and objective success were adopted. At a follow-up of <24 months, significant improvement was widely observed, even if with a heterogeneous rate of success between 32.7–90%, and a reinjection rate of 8.3–77.3%. Compared with other procedures, MUS resulted as significantly superior to UBAs but was balanced by a higher complication rate. Acute urinary retention, urinary tract infection and de novo urgency, and other complications, such as injection site rupture, urethral erosion and particle migration have been described after UBAs. SUI after UBAs treatment resulted in improvements in all studies and can be considered a safe and effective option to treat SUI. However, homogenous and longer-term data lack, limiting general recommendations. Thus, larger RCTs evaluating long-term effects are required.
Keywords: stress urinary incontinence; urinary incontinence; SUI; bulking agents; urethral bulking; UBA; mini-invasive stress urinary incontinence; urinary incontinence; SUI; bulking agents; urethral bulking; UBA; mini-invasive

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MDPI and ACS Style

Serati, M.; Braga, A.; Salvatore, S.; Torella, M.; Di Dedda, M.C.; Scancarello, C.; Cimmino, C.; De Rosa, A.; Frigerio, M.; Candiani, M.; et al. Up-to-Date Procedures in Female Stress Urinary Incontinence Surgery: A Concise Review on Bulking Agents Procedures. Medicina 2022, 58, 775. https://doi.org/10.3390/medicina58060775

AMA Style

Serati M, Braga A, Salvatore S, Torella M, Di Dedda MC, Scancarello C, Cimmino C, De Rosa A, Frigerio M, Candiani M, et al. Up-to-Date Procedures in Female Stress Urinary Incontinence Surgery: A Concise Review on Bulking Agents Procedures. Medicina. 2022; 58(6):775. https://doi.org/10.3390/medicina58060775

Chicago/Turabian Style

Serati, Maurizio, Andrea Braga, Stefano Salvatore, Marco Torella, Maria Carmela Di Dedda, Chiara Scancarello, Chiara Cimmino, Andrea De Rosa, Matteo Frigerio, Massimo Candiani, and et al. 2022. "Up-to-Date Procedures in Female Stress Urinary Incontinence Surgery: A Concise Review on Bulking Agents Procedures" Medicina 58, no. 6: 775. https://doi.org/10.3390/medicina58060775

APA Style

Serati, M., Braga, A., Salvatore, S., Torella, M., Di Dedda, M. C., Scancarello, C., Cimmino, C., De Rosa, A., Frigerio, M., Candiani, M., & Ruffolo, A. F. (2022). Up-to-Date Procedures in Female Stress Urinary Incontinence Surgery: A Concise Review on Bulking Agents Procedures. Medicina, 58(6), 775. https://doi.org/10.3390/medicina58060775

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