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Case Report

A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report

by
Simona De Summa
1,†,
Katia Danza
1,†,
Brunella Pilato
1,
Giuseppina Matera
1,
Rossella Fasano
2,
Angela Calabrese
3,
Rosanna Lacalamita
1,
Nicola Silvestris
2,4,
Stefania Tommasi
1,
Antonella Argentiero
2,‡ and
Oronzo Brunetti
2,*,‡
1
Molecular Diagnostics and Pharmacogenetics Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
2
Medical Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II” of Bari, 70124 Bari, Italy
3
Radiology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
4
Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
Last co-authors.
Medicina 2021, 57(11), 1241; https://doi.org/10.3390/medicina57111241
Submission received: 7 October 2021 / Revised: 8 November 2021 / Accepted: 11 November 2021 / Published: 13 November 2021
(This article belongs to the Special Issue Therapeutic Landscapes in Colorectal Carcinoma)
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Abstract

Colorectal cancer (CRC) is one of the most common cancer types around the world. The prognosis of patients with advanced diseases is still poor in spite of currently available therapeutic options. Regorafenib is an oral tyrosine kinase inhibitor (TKI) approved to treat refractory metastatic colorectal cancer (mCRC). We investigated Somatic mutations in several genes involved in immunological response and cancer progression in both long/short responder mCRC patients who underwent third-line therapy with regorafenib to identify predictive biomarkers of response using Ion Torrent PGM sequencing and bioinformatic tools. We found Somatic mutations in TGFBR1, TGFBR2, and TGFBR3 genes in primary tumor and metastases samples of long-responder patients. Furthermore, our bioinformatic results show that they were mainly enriched in immune response, cell junction, and cell adhesion in long responder patients, particularly in primary tumor and metastatic sites. These data suggest that the TGF-b pattern could be the leading actor of a prolonged response to this drug.
Keywords: colorectal cancer; TGF-b; regorafenib colorectal cancer; TGF-b; regorafenib

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MDPI and ACS Style

De Summa, S.; Danza, K.; Pilato, B.; Matera, G.; Fasano, R.; Calabrese, A.; Lacalamita, R.; Silvestris, N.; Tommasi, S.; Argentiero, A.; et al. A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report. Medicina 2021, 57, 1241. https://doi.org/10.3390/medicina57111241

AMA Style

De Summa S, Danza K, Pilato B, Matera G, Fasano R, Calabrese A, Lacalamita R, Silvestris N, Tommasi S, Argentiero A, et al. A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report. Medicina. 2021; 57(11):1241. https://doi.org/10.3390/medicina57111241

Chicago/Turabian Style

De Summa, Simona, Katia Danza, Brunella Pilato, Giuseppina Matera, Rossella Fasano, Angela Calabrese, Rosanna Lacalamita, Nicola Silvestris, Stefania Tommasi, Antonella Argentiero, and et al. 2021. "A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report" Medicina 57, no. 11: 1241. https://doi.org/10.3390/medicina57111241

APA Style

De Summa, S., Danza, K., Pilato, B., Matera, G., Fasano, R., Calabrese, A., Lacalamita, R., Silvestris, N., Tommasi, S., Argentiero, A., & Brunetti, O. (2021). A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report. Medicina, 57(11), 1241. https://doi.org/10.3390/medicina57111241

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