Prognostic Utility of Circulating Growth Factors in Aortic Valve Stenosis: A Pilot Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Subjects
2.2. Laboratory Assays
2.3. Statistical Analysis
3. Results
3.1. Patient Characteristics
3.2. GDF-15 Level Differences between the Patient Groups
3.3. VEGF-A Level Differences between the Patient Groups
3.4. FGF-2 Level Differences between the Patient Groups
3.5. FGF-21 Level Differences between the Patient Groups
3.6. Ang-2 Level Differences between the Patient Groups
3.7. Correlations between the Study Growth Factors
3.8. ROC Analysis of the Study Growth Factors
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Controls n = 30 | Mild Aortic Valve Stenosis n = 16 | Moderate Aortic Valve Stenosis n = 19 | Severe Aortic Valve Stenosis n = 11 | ||
---|---|---|---|---|---|
Gender (%) | Male Female | 6 (20) 24 (80) | 1 (6) 15 (94) | 8 (42) 11 (58) | 7 (64) 4 (36) |
Age (years) | Mdn (IQR) | 70 (60–75) | 72 (66–75) | 74 (65–79) | 69 (60–75) |
1 BMI | M (±SD) p-value vs. control | 27.97 (5.10) | 29.53 (4.97) p = 0.16 | 27.18 (4.76) p = 0.19 | 27.02 (4.04) p = 0.30 |
2 SV (mL) | M (±SD) p-value vs. control | 81.97 (22.20) | 72.13 (11.99) p = 0.26 | 79.89 (20.45) p = 0.45 | 78.09 (17.39) p = 0.12 |
3 EF (%) | M (±SD) p-value vs. control | 61.22 (6.44) | 57.58 (9.79) p = 0.17 | 61.32 (8,24) p = 0.17 | 57.73 (8,65) p = 0.15 |
4 SVI | M (±SD) p-value vs. control | 44.45 (11.19) | 39.26 (8.39) p = 0.38 | 42.36 (11.67) p = 0.51 | 41.97 (9.99) p = 0.11 |
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Hofmanis, J.; Tretjakovs, P.; Svirskis, S.; Gersone, G.; Hofmane, D.; Rozenberga, U.; Blumfelds, L.; Bahs, G.; Lejnieks, A.; Mackevics, V. Prognostic Utility of Circulating Growth Factors in Aortic Valve Stenosis: A Pilot Study. Medicina 2021, 57, 78. https://doi.org/10.3390/medicina57010078
Hofmanis J, Tretjakovs P, Svirskis S, Gersone G, Hofmane D, Rozenberga U, Blumfelds L, Bahs G, Lejnieks A, Mackevics V. Prognostic Utility of Circulating Growth Factors in Aortic Valve Stenosis: A Pilot Study. Medicina. 2021; 57(1):78. https://doi.org/10.3390/medicina57010078
Chicago/Turabian StyleHofmanis, Juris, Peteris Tretjakovs, Simons Svirskis, Gita Gersone, Dace Hofmane, Ulla Rozenberga, Leons Blumfelds, Guntis Bahs, Aivars Lejnieks, and Vitolds Mackevics. 2021. "Prognostic Utility of Circulating Growth Factors in Aortic Valve Stenosis: A Pilot Study" Medicina 57, no. 1: 78. https://doi.org/10.3390/medicina57010078