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Pharmaceuticals 2016, 9(3), 40;

Functions of Cationic Host Defense Peptides in Immunity

Manitoba Centre for Proteomics and Systems Biology, Departments of Internal Medicine and Immunology, University of Manitoba, Winnipeg, MB R3E3P4, Canada
Author to whom correspondence should be addressed.
Academic Editor: Guangshun Wang
Received: 2 June 2016 / Revised: 27 June 2016 / Accepted: 30 June 2016 / Published: 4 July 2016
(This article belongs to the Special Issue Antimicrobial Peptides: Expanded Activity Spectrum and Applications)
Full-Text   |   PDF [211 KB, uploaded 4 July 2016]


Cationic host defense peptides are a widely distributed family of immunomodulatory molecules with antimicrobial properties. The biological functions of these peptides include the ability to influence innate and adaptive immunity for efficient resolution of infections and simultaneous modulation of inflammatory responses. This unique dual bioactivity of controlling infections and inflammation has gained substantial attention in the last three decades and consequent interest in the development of these peptide mimics as immunomodulatory therapeutic candidates. In this review, we summarize the current literature on the wide range of functions of cationic host defense peptides in the context of the mammalian immune system. View Full-Text
Keywords: cationic host defense peptides; antimicrobial peptides; immunomodulation; inflammation cationic host defense peptides; antimicrobial peptides; immunomodulation; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hemshekhar, M.; Anaparti, V.; Mookherjee, N. Functions of Cationic Host Defense Peptides in Immunity. Pharmaceuticals 2016, 9, 40.

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