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Pharmaceuticals
Volume 18
Issue 11
10.3390/ph18111733
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Quinazoline-Derivatives of Imino-1,2,3-Dithiazoles Promote Biofilm Dispersion of Pseudomonas aeruginosa

by
Mathieu Gonzalez
1,2,
Anne-Sophie Tareau
1,2,
Daphnée de Crozals
3,
Corentin Layec
3,
Nathan Broudic
3,
Magalie Barreau
1,2,
Adrien Forge
1,2,
Olivier Lesouhaitier
1,2,
Corinne Fruit
3,
Sylvie Chevalier
1,2,
Thierry Besson
3,* and
Ali Tahrioui
1,2,*
1
Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, CBSA UR 4312, F-76000 Rouen, France
2
Plateforme de Sécurité Sanitaire Ébroïcienne (PSE), Univ Rouen Normandie, Normandie Univ, CBSA UR 4312, F-76000 Rouen, France
3
Univ Rouen Normandie, INSA Rouen Normandie, Univ Caen Normandie, ENSICAEN, CNRS, Institut CARMeN UMR 6064, F-76000 Rouen, France
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2025, 18(11), 1733; https://doi.org/10.3390/ph18111733
Submission received: 16 October 2025 / Revised: 7 November 2025 / Accepted: 10 November 2025 / Published: 14 November 2025
(This article belongs to the Special Issue Challenges in Discovering Innovations Related to Biofilms: Virulence, Spread, Control Strategies and Treatment)
Versions Notes

Abstract

Background/Objectives: Biofilm-associated infections pose a major clinical challenge since bacteria within biofilms exhibit highly antibiotic tolerance. Pseudomonas aeruginosa forms persistent biofilms that cause chronic infections in vulnerable patients, including those with cystic fibrosis, burns, or medical implants. Such biofilm-associated chronic infections require prolonged treatments that promote antimicrobial resistance. To address this, recent strategies focus on enhancing biofilm dispersion. Methods: Thirty-six N-arylimino-1,2,3-dithiazoles were screened for their biofilm dispersal activity using a crystal violet assay. Their cytotoxicity was assessed on A549 and HaCat eukaryotic cells. Moreover, their influence on bacterial growth and virulence was investigated. Lastly, fluorescence anisotropy was used to measure membrane fluidity to obtain the first insights on the mechanism of action of these chemicals. Results: Our results showed that quinazoline-derivatives of imino-1,2,3-dithiazoles display biofilm dispersion activity. These compounds do not increase virulence through pyocyanin production, do not modify the growth kinetics of P. aeruginosa, and do not show cytotoxicity towards eucaryotic cells. Conclusions: These findings highlight the potential use of N-arylimino-1,2,3-dithiazole-derived compounds as safe and effective dispersal agents of P. aeruginosa biofilms.
Keywords: Pseudomonas aeruginosa; N-arylimino-1,2,3-dithiazoles; biofilm dispersion Pseudomonas aeruginosa; N-arylimino-1,2,3-dithiazoles; biofilm dispersion

Share and Cite

MDPI and ACS Style

Gonzalez, M.; Tareau, A.-S.; de Crozals, D.; Layec, C.; Broudic, N.; Barreau, M.; Forge, A.; Lesouhaitier, O.; Fruit, C.; Chevalier, S.; et al. Quinazoline-Derivatives of Imino-1,2,3-Dithiazoles Promote Biofilm Dispersion of Pseudomonas aeruginosa. Pharmaceuticals 2025, 18, 1733. https://doi.org/10.3390/ph18111733

AMA Style

Gonzalez M, Tareau A-S, de Crozals D, Layec C, Broudic N, Barreau M, Forge A, Lesouhaitier O, Fruit C, Chevalier S, et al. Quinazoline-Derivatives of Imino-1,2,3-Dithiazoles Promote Biofilm Dispersion of Pseudomonas aeruginosa. Pharmaceuticals. 2025; 18(11):1733. https://doi.org/10.3390/ph18111733

Chicago/Turabian Style

Gonzalez, Mathieu, Anne-Sophie Tareau, Daphnée de Crozals, Corentin Layec, Nathan Broudic, Magalie Barreau, Adrien Forge, Olivier Lesouhaitier, Corinne Fruit, Sylvie Chevalier, and et al. 2025. "Quinazoline-Derivatives of Imino-1,2,3-Dithiazoles Promote Biofilm Dispersion of Pseudomonas aeruginosa" Pharmaceuticals 18, no. 11: 1733. https://doi.org/10.3390/ph18111733

APA Style

Gonzalez, M., Tareau, A.-S., de Crozals, D., Layec, C., Broudic, N., Barreau, M., Forge, A., Lesouhaitier, O., Fruit, C., Chevalier, S., Besson, T., & Tahrioui, A. (2025). Quinazoline-Derivatives of Imino-1,2,3-Dithiazoles Promote Biofilm Dispersion of Pseudomonas aeruginosa. Pharmaceuticals, 18(11), 1733. https://doi.org/10.3390/ph18111733

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