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Correction

Correction: Juhás et al. Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole. Pharmaceuticals 2022, 15, 580

by
Martin Juhás
1,*,
Andrea Bachtíková
1,
Daria Elżbieta Nawrot
1,
Paulína Hatoková
1,
Vinod Sukanth Kumar Pallabothula
1,
Adéla Diepoltová
1,
Ondřej Janďourek
1,
Pavel Bárta
1,
Klára Konečná
1,
Pavla Paterová
2,
Vít Šesták
3 and
Jan Zitko
1,*
1
Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
2
Department of Clinical Microbiology, University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic
3
Department of Clinical Biochemistry and Diagnostics, Faculty of Medicine in Hradec Králové, University Hospital, Sokolská 581, 500 05 Hradec Králové, Czech Republic
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2023, 16(3), 384; https://doi.org/10.3390/ph16030384
Submission received: 13 February 2023 / Accepted: 21 February 2023 / Published: 2 March 2023
(This article belongs to the Section Medicinal Chemistry)
In the original publication [1], there was a mistake in assigning individual compounds to their structural subtype in Figure 2 and Table 1. In correction, subtype I comprises compounds 110, and subtype II comprises compounds 1120. Also, for compounds 1113 in Table 1, we unified the naming of the Ar substituent, using the pyridinyl convention instead of pyridyl (to achieve consistency with the rest of the paper). The corrected Figure 2 and Table 1 appear below. We made the same changes to Table S2 in the Supplementary Material. The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. This correction was approved by the academic editor. The original publication has also been updated.

Reference

  1. Juhás, M.; Bachtíková, A.; Nawrot, D.E.; Hatoková, P.; Pallabothula, V.S.K.; Diepoltová, A.; Janďourek, O.; Bárta, P.; Konečná, K.; Paterová, P.; et al. Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole. Pharmaceuticals 2022, 15, 580. [Google Scholar] [CrossRef] [PubMed]
Figure 2. Synthetic procedure used to prepare title compounds. Conditions: a: (for X = S) 1.1 eq. urea, in EtOH, reflux 2 h; b: (for X = O) 10 eq. urea, in MeCN, reflux 16 h or in DMF, 120 °C 2 h; c: 1 eq. acyl chloride, 3 eq. DIPEA or pyridine, in DCM, overnight; d: 10 eq. thionyl chloride, catalytic DMF.
Figure 2. Synthetic procedure used to prepare title compounds. Conditions: a: (for X = S) 1.1 eq. urea, in EtOH, reflux 2 h; b: (for X = O) 10 eq. urea, in MeCN, reflux 16 h or in DMF, 120 °C 2 h; c: 1 eq. acyl chloride, 3 eq. DIPEA or pyridine, in DCM, overnight; d: 10 eq. thionyl chloride, catalytic DMF.
Pharmaceuticals 16 00384 g001
Table 1. Structures, log k’w, HepG2 cytotoxicity, and MIC against Mtb H37Ra of the title compounds.
Table 1. Structures, log k’w, HepG2 cytotoxicity, and MIC against Mtb H37Ra of the title compounds.
StructureCodeArXlog k’wHepG2
IC50 (µM)
Mtb H37Ra
MIC (µg/mL)
Pharmaceuticals 16 00384 i0011apyridin-2-ylS1.857>1000 *31.25
1bpyridin-2-ylO0.854>1000 *62.5
2apyridin-3-ylS1.251>1000 *250
2bpyridin-3-ylO0.436>1000 *31.25
3apyridin-4-ylS1.306>1000 *250
3bpyridin-4-ylO0.396>1000 *15.625
4b5-Me-pyridin-3-ylO0.888>1000 *7.81
5b2-Me-pyridin-4-ylO0.714>1000 *3.91
6a2-Cl-pyridin-4-ylS2.013>250 **≥500
6b2-Cl-pyridin-4-ylO1.136664.13.125
7a2-Cl-6-Me-pyridin-4-ylS2.319>250 **≥500
7b2-Cl-6-Me-pyridin-4-ylO1.430959.4<3.91
8apyrazin-2-ylS1.222n.d.62.5
8bpyrazin-2-ylO0.154n.d.31.25
9a5-Cl-pyrazin-2-ylS1.941n.d.31.25
9b5-Cl-pyrazin-2-ylO0.958n.d.31.25
10aquinoxalin-2-ylS2.530>50 **≥250
10bquinoxalin-2-ylO1.493>1000 *15.625
Pharmaceuticals 16 00384 i00211apyridin-2-ylS3.102>100 **3.91
11bpyridin-2-ylO2.038883.43.91
12apyridin-3-ylS2.131>25 **≥500
12bpyridin-3-ylO1.118610.3125
13apyridin-4-ylS2.190>100 **7.81
13bpyridin-4-ylO1.163879.331.25
14b5-Me-pyridin-3-ylO1.478>100 **≥250
15a2-Cl-pyridin-4-ylS3.036102.63.91
15b2-Cl-pyridin-4-ylO1.992136.17.81
16a2-Cl-6-Me-pyridin-4-ylS3.314n.d.7.81
16b2-Cl-6-Me-pyridin-4-ylO2.251n.d.15.625
17apyrazin-2-ylS2.365n.d.>50 [11]
17bpyrazin-2-ylO1.306>1000 *15.625
18a5-Cl-pyrazin-2-ylS3.173n.d.>100 [11]
18b5-Cl-pyrazin-2-ylO2.073>100 **15.625
19aquinoxalin-2-ylS3.583n.d.≥500
19bquinoxalin-2-ylO2.465n.d.≥500
20bphenylO2.090330.362.5
CIP----0.25
INH----0.25
RIF----0.003–0.0015
* IC50 above the highest tested concentration; ** exact IC50 value could not be determined due to insolubility in the testing medium at higher concentrations; CIP—ciprofloxacin; INH—isoniazid; RIF—rifampicin; n.d.—not determined.
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MDPI and ACS Style

Juhás, M.; Bachtíková, A.; Nawrot, D.E.; Hatoková, P.; Pallabothula, V.S.K.; Diepoltová, A.; Janďourek, O.; Bárta, P.; Konečná, K.; Paterová, P.; et al. Correction: Juhás et al. Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole. Pharmaceuticals 2022, 15, 580. Pharmaceuticals 2023, 16, 384. https://doi.org/10.3390/ph16030384

AMA Style

Juhás M, Bachtíková A, Nawrot DE, Hatoková P, Pallabothula VSK, Diepoltová A, Janďourek O, Bárta P, Konečná K, Paterová P, et al. Correction: Juhás et al. Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole. Pharmaceuticals 2022, 15, 580. Pharmaceuticals. 2023; 16(3):384. https://doi.org/10.3390/ph16030384

Chicago/Turabian Style

Juhás, Martin, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Adéla Diepoltová, Ondřej Janďourek, Pavel Bárta, Klára Konečná, Pavla Paterová, and et al. 2023. "Correction: Juhás et al. Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole. Pharmaceuticals 2022, 15, 580" Pharmaceuticals 16, no. 3: 384. https://doi.org/10.3390/ph16030384

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