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Long Term Effectiveness of Photodynamic Therapy for CIN Treatment

São Carlos Institute of Physics, University of Sao Paulo, São Carlos 13566-590, Brazil
Woman Health Ambulatory, Uniara 14801-308, Brazil
TruCytonics LLC, Rockville, MD 20851, USA
Department of Morphology and Pathology, Federal University of São Carlos, São Carlos 13565-905, Brazil
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(3), 107;
Received: 16 May 2019 / Revised: 21 June 2019 / Accepted: 29 June 2019 / Published: 12 July 2019
(This article belongs to the Special Issue Photodynamic Therapy 2019)
PDF [4461 KB, uploaded 12 July 2019]


(1) Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in women worldwide. The highest incidence rates are in Africa, followed by South-Central Asia and South America. According to the Brazilian National Institute of Cancer (INCA), 16,370 new cases of cervical cancer were estimated for each year of the biennium of 2018–2019. About 90% of cervical cancers originate from the malignant progression of cervical intraepithelial neoplasia (CIN) which is classified based on cytohistological characteristics (low- and high-grade lesions). The present study reports the long-term effectiveness of topical photodynamic therapy (PDT) for CIN grades 1 and 2/3 with up to two years of follow up. (2) Methods: A total of 56 patients with CIN 1, ten with CIN 2, and 14 patients for the placebo group were enrolled in this study. (3) Results: 75% (n = 42) of CIN 1 patients presented a complete response to PDT and only 23.2% (n = 13) of recurrence, progression, and/or lesions remaining two years after PDT. For CIN 2/3 patients, 90% were observed to be cured after one and two years of follow up. (4) Conclusions: PDT presented best results two years after a non-invasive, fast, and low-cost procedure and in comparison with the placebo group, preventing the progression of cervical intraepithelial neoplasia and preserving the cervix. View Full-Text
Keywords: cervical cancer; cervical intraepithelial neoplasia; human papillomavirus; photodynamic therapy; methyl aminolevulinate cervical cancer; cervical intraepithelial neoplasia; human papillomavirus; photodynamic therapy; methyl aminolevulinate

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Inada, N.M.; Buzzá, H.H.; Leite, M.F.M.; Kurachi, C.; Trujillo, J.R.; de Castro, C.A.; Carbinatto, F.M.; Lombardi, W.; Bagnato, V.S. Long Term Effectiveness of Photodynamic Therapy for CIN Treatment. Pharmaceuticals 2019, 12, 107.

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