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Pharmaceuticals 2018, 11(4), 118; https://doi.org/10.3390/ph11040118

Lipid Nanoparticles and Their Hydrogel Composites for Drug Delivery: A Review

1
CEA LETI MlNATEC Campus, University Grenoble Alpes, F-38000 Grenoble, France
2
CERMAV-CNRS, University Grenoble Alpes, F-38000 Grenoble, France
*
Author to whom correspondence should be addressed.
Received: 26 September 2018 / Revised: 15 October 2018 / Accepted: 18 October 2018 / Published: 1 November 2018
(This article belongs to the Special Issue Nano Drug Carriers)
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Abstract

Several drug delivery systems already exist for the encapsulation and subsequent release of lipophilic drugs that are well described in the scientific literature. Among these, lipid nanoparticles (LNP) have specifically come up for dermal, transdermal, mucosal, intramuscular and ocular drug administration routes in the last twenty years. However, for some of them (especially dermal, transdermal, mucosal), the LNP aqueous dispersions display unsuitable rheological properties. They therefore need to be processed as semi-solid formulations such as LNP-hydrogel composites to turn into versatile drug delivery systems able to provide precise spatial and temporal control of active ingredient release. In the present review, recent developments in the formulation of lipid nanoparticle-hydrogel composites are highlighted, including examples of successful encapsulation and release of lipophilic drugs through the skin, the eyes and by intramuscular injections. In relation to lipid nanoparticles, a specific emphasis has been put on the LNP key properties and how they influence their inclusion in the hydrogel. Polymer matrices include synthetic polymers such as poly(acrylic acid)-based materials, environment responsive (especially thermo-sensitive) polymers, and innovative polysaccharide-based hydrogels. The composite materials constitute smart, tunable drug delivery systems with a wide range of features, suitable for dermal, transdermal, and intramuscular controlled drug release. View Full-Text
Keywords: lipid nanoparticles; hydrogels; polysaccharides; solid lipid nanoparticles; nanostructured lipid carriers; chitosan; dextran; cellulose; alginate lipid nanoparticles; hydrogels; polysaccharides; solid lipid nanoparticles; nanostructured lipid carriers; chitosan; dextran; cellulose; alginate
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Desfrançois, C.; Auzély, R.; Texier, I. Lipid Nanoparticles and Their Hydrogel Composites for Drug Delivery: A Review. Pharmaceuticals 2018, 11, 118.

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