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Pharmaceuticals 2018, 11(4), 92; https://doi.org/10.3390/ph11040092

Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release

1
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy
2
Macrofarm s.r.l., C/O Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, 87036 Rende (CS), Italy
3
Department of Science, University of Basilicata, 85100 Potenza, Italy
*
Author to whom correspondence should be addressed.
Received: 18 July 2018 / Revised: 15 September 2018 / Accepted: 20 September 2018 / Published: 22 September 2018
(This article belongs to the Special Issue Nano Drug Carriers)
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Abstract

The aim of the present study was the development of a “smart bandage” for the topical administration of diclofenac, in the treatment of localized painful and inflammatory conditions, incorporating Molecularly Imprinted Polymers (MIPs) for the controlled release of this anti-inflammatory drug. For this purpose, MIP spherical particles were synthesized by precipitation polymerization, loaded with the therapeutic agent and incorporated into the bandage surface. Batch adsorption binding studies were performed to investigate the adsorption isotherms and kinetics and the selective recognition abilities of the synthesized MIP. In vitro diffusion studies were also carried out using Franz cells and the obtained results were reported as percentage of the diffused dose, cumulative amount of diffused drug, steady-state drug flux and permeability coefficient. Moreover, the biocompatibility of the developed device was evaluated using the EPISKIN™ model. The Scatchard analysis indicated that the prepared MIP is characterized by the presence of specific binding sites for diclofenac, which are not present in the corresponding non-imprinted polymer, and the obtained results confirmed both the ability of the prepared bandage to prolong the drug release and the absence of skin irritation reactions. Therefore, these results support the potential application of the developed “smart bandage” as topical device for diclofenac sustained release. View Full-Text
Keywords: Molecularly Imprinted Polymers (MIPs); Diclofenac; controlled release; smart bandage; in vitro diffusion studies; adsorption and release kinetics; skin irritation; precipitation polymerization Molecularly Imprinted Polymers (MIPs); Diclofenac; controlled release; smart bandage; in vitro diffusion studies; adsorption and release kinetics; skin irritation; precipitation polymerization
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Parisi, O.I.; Ruffo, M.; Scrivano, L.; Malivindi, R.; Vassallo, A.; Puoci, F. Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release. Pharmaceuticals 2018, 11, 92.

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